INT288700

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cp, Tfrc) endosome (Tfrc) mitochondrion (Tfrc)
transport (Cp) extracellular space (Cp) peptidase activity (Tfrc)
Cp (Mus musculus)
Tfrc (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 44 92.56 High High
imagery 10 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 8 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Iron Overload 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon binding the TfR, the Tf-TfR complex usually internalizes to endosome, where iron is released from Tf, reduced from the ferric (Fe3+) to the ferrous (Fe2+) form, exported to cytosol by DMT1, and then exported out of the cell by FPN, with the aid of ferroxidases such as ceruloplasmin and hephaestin.
ceruloplasmin Binding (internalizes) of TfR
1) Confidence 0.40 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0 Pain Relevance 0.20
Upon binding the TfR, the Tf-TfR complex usually internalizes to endosome, where iron is released from Tf, reduced from the ferric (Fe3+) to the ferrous (Fe2+) form, exported to cytosol by DMT1, and then exported out of the cell by FPN, with the aid of ferroxidases such as ceruloplasmin and hephaestin.
ferroxidase Binding (internalizes) of TfR
2) Confidence 0.40 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0 Pain Relevance 0.19

General Comments

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