INT28871

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Context Info
Confidence 0.46
First Reported 1988
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.29
Pain Relevance 4.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CSRP1)
Anatomy Link Frequency
blood 1
white blood cells 1
CSRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 53 99.58 Very High Very High Very High
ischemia 5 99.20 Very High Very High Very High
Restless leg syndrome 240 98.80 Very High Very High Very High
lidocaine 4 98.44 Very High Very High Very High
aspirin 44 97.64 Very High Very High Very High
adenocard 1 91.44 High High
headache 1 89.16 High High
abdominal pain 2 86.80 High High
Inflammatory response 31 82.40 Quite High
Pain 14 81.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 108 99.58 Very High Very High Very High
Cv Unclassified Under Development 21 99.20 Very High Very High Very High
Vasculitis 10 99.14 Very High Very High Very High
Increased Venous Pressure Under Development 251 98.80 Very High Very High Very High
Vomiting 1 98.60 Very High Very High Very High
Fatigue 1 98.50 Very High Very High Very High
Disease 3 98.32 Very High Very High Very High
Constipation 1 98.32 Very High Very High Very High
Anorexia 1 98.02 Very High Very High Very High
Obesity 4 97.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRP levels were unaffected by exercise in the patients with IC or healthy volunteers (table 2).


Neg (unaffected) Regulation (unaffected) of CRP associated with restless leg syndrome
1) Confidence 0.46 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.66 Pain Relevance 0.66
Only one previous study has examined the effect of exercise on IL-6 levels, a precursor of CRP, and shown this to be increased pre and post-exercise in 20 patients with IC compared to 20 healthy controls [6].
Spec (examined) Regulation (effect) of CRP associated with restless leg syndrome
2) Confidence 0.34 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 1.14 Pain Relevance 0.88
CRP values were elevated.
Regulation (values) of CRP
3) Confidence 0.24 Published 2002 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 12444563 Disease Relevance 0 Pain Relevance 0
In elderly subjects with diabetes or obesity, longer cumulative averages also resulted in the greatest effects on inflammation in a study of PM2.5 effects on CRP, IL-6, and white blood cells (Dubowsky et al. 2006).
Regulation (effects) of CRP in white blood cells associated with inflammation, diabetes mellitus and obesity
4) Confidence 0.23 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.59 Pain Relevance 0.17
The effect of acute exercise on high sensitivity CRP has not been reported before, but exercise training has been shown to reduce levels of CRP [2,25].
Regulation (effect) of CRP
5) Confidence 0.20 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 1.11 Pain Relevance 0.88
Baseline hsCRP values were higher in patients with IC compared to volunteers (p = 0.035).
Regulation (values) of hsCRP associated with restless leg syndrome
6) Confidence 0.18 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.60 Pain Relevance 0.60
Inappetence, exhaustion and fatigue, although characteristic of GCA, as well as blood count, alpha-globulins, CRP and alkaline serum phosphatase were of no value in differentiating between GCA and other diseases.
Neg (no) Regulation (value) of CRP in blood associated with fatigue, anorexia, disease and vasculitis
7) Confidence 0.16 Published 1988 Journal Z Gerontol Section Abstract Doc Link 3239146 Disease Relevance 1.34 Pain Relevance 0.09
Variables used were as follows: (1) age, (2) sex, (3) constipation, (4) vomiting, (5) peak value of WBC count (/microliter) after admission, (6) peak value of log CRP (microgram/dl), (7) presence of ulcerative lesion in endoscopic findings in acute stage.
Regulation (value) of CRP associated with constipation and vomiting
8) Confidence 0.16 Published 1998 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 9889542 Disease Relevance 0.51 Pain Relevance 0.17
Lidocaine (10(-5) or 3 x 10(-5) M) improved the mechanical function and attenuated the changes in NEFA, ATP, CrP, and ECP caused by ischemia.
Regulation (changes) of CrP associated with ischemia and lidocaine
9) Confidence 0.15 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2806383 Disease Relevance 0.34 Pain Relevance 0.60

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