INT288754

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mtr) intracellular (Mtr) cytoplasm (Mtr)
Anatomy Link Frequency
liver 2
Mtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 6 94.24 High High
Paracetamol 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 98.52 Very High Very High Very High
Toxicity 4 5.00 Very Low Very Low Very Low
Alcohol Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been extensively documented that in vivo inhibition of methionine synthase induced by ethanol plays a critical role in hepatotoxicity and the administration of ethanol depletes hepatic S-adenosylmethionine which protects the liver from ethanol-induced fatty infiltration (Barak et al., 2001; Barak et al., 2003).
Negative_regulation (inhibition) of Positive_regulation (induced) of methionine synthase in liver associated with hepatotoxicity
1) Confidence 0.11 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788200 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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