INT28878

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 10.34
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
blood 6
salivary gland 4
upper 2
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 25 98.84 Very High Very High Very High
peptic ulcer disease 18 93.12 High High
antagonist 4 83.32 Quite High
cINOD 2 74.60 Quite High
alcohol 2 73.08 Quite High
Bile 4 64.12 Quite High
Disease Link Frequency Relevance Heat
Infection 1 98.64 Very High Very High Very High
Nicotine Addiction 69 98.58 Very High Very High Very High
Ulcers 41 98.12 Very High Very High Very High
Duodenal Ulcer 3 95.08 Very High Very High Very High
Gastritis 4 94.24 High High
Disease 18 93.12 High High
Congenital Anomalies 1 90.76 High High
Recurrence 11 89.28 High High
Apoptosis 4 78.48 Quite High
Stress 2 75.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cigarette smoking and nicotine reduce the level of circulating epidermal growth factor (EGF) and decrease the secretion of EGF from the salivary gland, which are necessary for gastric mucosal cell renewal.
Negative_regulation (decrease) of Localization (secretion) of EGF in salivary gland associated with nicotine addiction and nicotine
1) Confidence 0.49 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.42 Pain Relevance 0.51
Cigarette smoking and nicotine reduce the level of circulating epidermal growth factor (EGF) and decrease the secretion of EGF from the salivary gland, which are necessary for gastric mucosal cell renewal.
Negative_regulation (decrease) of Localization (secretion) of EGF in salivary gland associated with nicotine addiction and nicotine
2) Confidence 0.35 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.42 Pain Relevance 0.51
Decreased salivary secretion of epidermal growth factor and gastric Campylobacter pylori infections have also received much attention recently.
Negative_regulation (Decreased) of Localization (secretion) of epidermal growth factor associated with infection
3) Confidence 0.23 Published 1989 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 2809136 Disease Relevance 1.36 Pain Relevance 0.21
Epidermal growth factor (EGF) is produced in the salivary and Brunner's glands of the upper gastrointestinal tract, inhibits gastric acid secretion, and is a powerful mitogen.
Negative_regulation (inhibits) of Localization (secretion) of EGF in upper
4) Confidence 0.13 Published 1996 Journal Helicobacter Section Abstract Doc Link 9398872 Disease Relevance 0.78 Pain Relevance 0.07
It decreases gastric mucosal blood flow and inhibits gastric mucous secretion, gastric prostaglandin generation, salivary epidermal growth factor secretion, duodenal mucosal bicarbonate secretion, and pancreatic bicarbonate secretion.
Negative_regulation (inhibits) of Localization (secretion) of epidermal growth factor in blood
5) Confidence 0.04 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479620 Disease Relevance 1.77 Pain Relevance 0.42
It decreases gastric mucosal blood flow and inhibits gastric mucous secretion, gastric prostaglandin generation, salivary epidermal growth factor secretion, duodenal mucosal bicarbonate secretion, and pancreatic bicarbonate secretion.
Negative_regulation (inhibits) of Localization (secretion) of epidermal growth factor in blood
6) Confidence 0.03 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479620 Disease Relevance 1.80 Pain Relevance 0.43
It decreases gastric mucosal blood flow and inhibits gastric mucous secretion, gastric prostaglandin generation, salivary epidermal growth factor secretion, duodenal mucosal bicarbonate secretion, and pancreatic bicarbonate secretion.
Negative_regulation (inhibits) of Localization (secretion) of epidermal growth factor in blood
7) Confidence 0.03 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479620 Disease Relevance 1.79 Pain Relevance 0.42

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