INT288817

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 6.19
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rasgrf2) plasma membrane (Rasgrf2) intracellular (Rasgrf2)
cytoplasm (Rasgrf2)
Anatomy Link Frequency
T-cell 3
thymus 1
Rasgrf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 9 80.16 Quite High
Pain 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 396 99.72 Very High Very High Very High
Leukemia 189 99.54 Very High Very High Very High
Cancer 585 99.12 Very High Very High Very High
Autoimmune Disease 18 98.64 Very High Very High Very High
Disease 63 98.00 Very High Very High Very High
Lymphopenia 18 96.28 Very High Very High Very High
Aging 18 90.00 High High
Colon Cancer 18 74.96 Quite High
Lymphadenopathy 18 59.72 Quite High
Hyperplasia 9 57.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combined inactivation of the Rasgrf2 and Vav1 loci did not aggravate the thymocyte developmental/selection defects or the T–cell lymphopenia induced by the single Vav1 gene deficiency (Figure 3).
Negative_regulation (inactivation) of Rasgrf2 in T-cell associated with lymphopenia
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.31 Pain Relevance 0
On the other hand, recent observations have shown that RASGRF2, a human gene encoding a dual GEF with specificity for Ras and Rho/Rac proteins, is either hypermethylated or downregulated transcriptionally in cancer cell lines and primary tumors [12]-[15], a biological property reminiscent of genes associated with tumor suppressor activities.
Negative_regulation (downregulated) of RASGRF2 associated with cancer
2) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.48 Pain Relevance 0
These results suggest that the influence of the Rasgrf2 gene loss on lymphomagenesis is totally contingent on the prior disruption of Vav1 function in the T–cell compartment.
Negative_regulation (loss) of Rasgrf2 in T-cell
3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.79 Pain Relevance 0
These results indicated that the Vav1 proto–oncogene deficiency in mice leads in the long–term to leukemia/lymphoma and that the loss of the Rasgrf2 gene further accentuates the progression of that disease.


Negative_regulation (loss) of Rasgrf2 associated with leukemia, lymphatic system cancer and disease
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.22 Pain Relevance 0
Hence, these results indicate that young animals do not have neoplasic or pre–neoplasic manifestations and that the inactivation of the Rasgrf2 gene does not accentuate the already severe immune defects caused by the Vav1–deficiency.
Negative_regulation (inactivation) of Rasgrf2
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.47 Pain Relevance 0
However, when combined with the inactivation of the Vav1 gene, the Rasgrf2 gene deficiency promotes a two–fold increase in the development of “widespread” lymphomas, shorter latency periods for the development of the disease, and enhanced mortality/sickness rates.
Negative_regulation (deficiency) of Rasgrf2 associated with lymphatic system cancer and disease
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.80 Pain Relevance 0
Unexpectedly, we found that the loss of Vav1 and Rasgrf2 genes cooperated synergistically in the development of very aggressive T–cell lymphomas in mice.
Negative_regulation (loss) of Rasgrf2 in T-cell associated with lymphatic system cancer
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.47 Pain Relevance 0.04
The single Rasgrf2 deficiency has only minor or no effects per se in promoting the widespread and thymus–localized subset of tumors, respectively.
Negative_regulation (deficiency) of Rasgrf2 in thymus associated with cancer
8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.80 Pain Relevance 0
The Vav1 and Rasgrf2 gene deficiencies seem to contribute differently to these two lymphoma stages.
Negative_regulation (deficiencies) of Rasgrf2 associated with lymphatic system cancer
9) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.84 Pain Relevance 0

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