INT288818

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Context Info
Confidence 0.77
First Reported 2009
Last Reported 2009
Negated 0
Speculated 4
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 12.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rasgrf2) plasma membrane (Rasgrf2) intracellular (Rasgrf2)
cytoplasm (Rasgrf2)
Anatomy Link Frequency
colon 2
T-cell 1
Rasgrf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 15 24.72 Low Low
cytokine 15 9.76 Low Low
Disease Link Frequency Relevance Heat
Cancer 975 100.00 Very High Very High Very High
Lymphatic System Cancer 660 100.00 Very High Very High Very High
Leukemia 315 100.00 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 90 99.34 Very High Very High Very High
Hematologic Neoplasms 15 98.28 Very High Very High Very High
Colon Cancer 30 97.88 Very High Very High Very High
Chronic Myeloid Leukemia 15 97.68 Very High Very High Very High
Htlv Types I And Ii 15 96.56 Very High Very High Very High
Chronic Lymphoid Leukemia 60 95.20 Very High Very High Very High
Multiple Myeloma 15 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the RT–PCR data, we found no significant variations in the expression levels of the RASGRF2 mRNA in the microarray data available at the Oncomine site, indicating that this gene is not commonly deregulated at least in the case of the hematopoietic tumors selected in this study.
Gene_expression (expression) of RASGRF2 associated with cancer
1) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.14 Pain Relevance 0
To this end, we first used a standard bioinformatics comparison tool available in that database to investigate whether the expression of VAV1 and/or RASGRF2 genes was deregulated in hematopoietic tumor cells relative to their normal cell counterparts.
Spec (whether) Gene_expression (expression) of RASGRF2 associated with cancer
2) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.14 Pain Relevance 0
They also suggest that the inactivation of Vav1 function may represent an inadequate strategy to treat T–cell lymphomas, especially those associated with low levels of Rasgrf2 gene expression.



Gene_expression (expression) of Rasgrf2 in T-cell associated with lymphatic system cancer
3) Confidence 0.77 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2788417 Disease Relevance 0.70 Pain Relevance 0
We next analyzed whether the expression levels of VAV1 and RASGRF2 genes were significantly altered in specific subgroups of patients affected of leukemia, lymphoma or myeloma.
Spec (whether) Gene_expression (levels) of RASGRF2 associated with leukemia and lymphatic system cancer
4) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.12 Pain Relevance 0
However, our present data puts a note of caution on those possible avenues, since they indicate that the blockage of Vav family–dependent signaling could be highly counterproductive in the case of lymphoblastic lymphoma patients with reduced levels of RASGRF2 gene expression in tumor cells.
Gene_expression (expression) of RASGRF2 associated with cancer and precursor cell lymphoblastic leukemia-lymphoma
5) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.87 Pain Relevance 0
We next analyzed whether the expression levels of VAV1 and RASGRF2 genes were significantly altered in specific subgroups of patients affected of leukemia, lymphoma or myeloma.
Spec (whether) Gene_expression (expression) of RASGRF2 associated with leukemia and lymphatic system cancer
6) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.12 Pain Relevance 0
Consistent with this possibility, it has been recently demonstrated that the overexpression of RasGRF2 affects negatively the transforming properties of a colon cancer cell line [15].
Gene_expression (overexpression) of RasGRF2 in colon associated with colon cancer
7) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.54 Pain Relevance 0
The take home message of these studies is that the human VAV1 and RASGRF2 genes do not show a consistent and generalizable change pattern in hematopoietic tumors such as lymphomas, leukemias or myelomas.
Gene_expression (genes) of RASGRF2 associated with leukemia, lymphatic system cancer and cancer
8) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.02 Pain Relevance 0
The above observations indicated that the deletion of the Vav1 and/or Rasgrf2 gene could play a role in the development of lymphoid tumors in humans.
Gene_expression (deletion) of Rasgrf2 associated with cancer
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.18 Pain Relevance 0
The settings for the searches were: gene: VAV1 or RASGRF2; cancer type: leukemia, lymphoma and myeloma; dataset size: microarray data containing a minimum of 75 independent samples; microarray platform: unrestricted; gene rank: top 10%; P value?
Gene_expression (lymphoma) of RASGRF2 associated with leukemia, lymphatic system cancer and cancer
10) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.54 Pain Relevance 0
The settings for the searches were: gene: VAV1 or RASGRF2; cancer type: leukemia, lymphoma and myeloma; dataset size: microarray data containing a minimum of 75 independent samples; microarray platform: unrestricted; gene rank: top 10%; P value?
Gene_expression (leukemia) of RASGRF2 associated with leukemia, lymphatic system cancer and cancer
11) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.54 Pain Relevance 0
Number LYRT101, Origene Technologies) was used to analyze the expression of VAV1 and RASGRF2 transcripts in different subsets of lymphomas.
Spec (analyze) Gene_expression (expression) of RASGRF2 associated with lymphatic system cancer
12) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.37 Pain Relevance 0
Moreover, it has been demonstrated that the overexpression of RasGRF2 negatively affects the transforming properties of a colon cancer cell line [15].
Gene_expression (overexpression) of RasGRF2 in colon associated with colon cancer
13) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.69 Pain Relevance 0
The settings for the searches were: gene: VAV1 or RASGRF2; cancer type: leukemia, lymphoma and myeloma; dataset size: microarray data containing a minimum of 75 independent samples; microarray platform: unrestricted; gene rank: top 10%; P value?
Gene_expression (size) of RASGRF2 associated with leukemia, lymphatic system cancer and cancer
14) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.54 Pain Relevance 0
These results suggest that the changes in the expression profile of VAV1 and RASGRF2 genes are not a general event associated to the progression of hematopoietic tumors.
Gene_expression (expression) of RASGRF2 associated with cancer
15) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.25 Pain Relevance 0

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