INT288827

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rasgrf2, Vav1) endoplasmic reticulum (Rasgrf2) plasma membrane (Rasgrf2)
cytoplasm (Rasgrf2)
Rasgrf2 (Mus musculus)
Vav1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 65 98.14 Very High Very High Very High
Colon Cancer 2 55.52 Quite High
Lymphatic System Cancer 44 51.28 Quite High
Leukemia 21 50.48 Quite High
Targeted Disruption 1 50.00 Quite Low
Precursor Cell Lymphoblastic Leukemia-lymphoma 6 26.32 Quite Low
Disease 7 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Chronic Lymphoid Leukemia 4 5.00 Very Low Very Low Very Low
Lymphopenia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the lack of CD69 expression in the Vav1–/–;Rasgrf2–/– tumor cells suggests that their growth is mediated by TCR–independent mechanisms, the synergistic interaction between the Vav1 and Rasgrf2 gene deficiencies will probably need the alteration of TCR–independent routes rather than the canonical TCR downstream pathways for this hypothesis to be correct.
Rasgrf2 Binding (interaction) of Vav1 associated with cancer
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.37 Pain Relevance 0

General Comments

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