INT288828

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rasgrf2) plasma membrane (Rasgrf2) intracellular (Rasgrf2)
cytoplasm (Rasgrf2)
ras (Mus musculus)
Rasgrf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 65 96.52 Very High Very High Very High
Colon Cancer 2 69.76 Quite High
Targeted Disruption 1 50.00 Quite Low
Lymphatic System Cancer 44 13.24 Low Low
Leukemia 21 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Precursor Cell Lymphoblastic Leukemia-lymphoma 6 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Chronic Lymphoid Leukemia 4 5.00 Very Low Very Low Very Low
Lymphopenia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, recent observations have shown that RASGRF2, a human gene encoding a dual GEF with specificity for Ras and Rho/Rac proteins, is either hypermethylated or downregulated transcriptionally in cancer cell lines and primary tumors [12]-[15], a biological property reminiscent of genes associated with tumor suppressor activities.
Ras Binding (specificity) of RASGRF2 associated with cancer
1) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.41 Pain Relevance 0

General Comments

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