INT288829

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rhoa, Rac1) intracellular (Rhoa, Rac1) GTPase activity (Rhoa, Rac1)
cytoplasm (Rhoa, Rac1) cell adhesion (Rhoa, Rac1) cell differentiation (Rhoa)
Anatomy Link Frequency
bar 2
Rhoa (Mus musculus)
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 65 92.64 High High
Mevalonate Kinase Deficiency 232 92.56 High High
Precursor Cell Lymphoblastic Leukemia-lymphoma 6 91.04 High High
Colon Cancer 2 61.76 Quite High
Sprains And Strains 5 51.64 Quite High
Targeted Disruption 1 50.00 Quite Low
Lymphatic System Cancer 44 46.08 Quite Low
Leukemia 21 5.00 Very Low Very Low Very Low
Fever 20 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in total cellular levels of active RhoA and Rac1 due to simvastatin appears primarily, if not solely, caused by activation of soluble RhoA and Rac1 and not membrane-bound RhoA and Rac1.
RhoA Binding (bound) of Rac1
1) Confidence 0.21 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.11 Pain Relevance 0
Equal amounts of cell lysate (a, d) were analyzed for relative levels of active RhoA (b) and active Rac1 (e) associated with the membranes (white bar set as 100%) and relative soluble levels of active RhoA (c) and active Rac1 (f) (black bar set as 100%).
RhoA Binding (associated) of Rac1 in bar
2) Confidence 0.21 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.50 Pain Relevance 0
The increase in total cellular levels of active RhoA and Rac1 due to simvastatin appears primarily, if not solely, caused by activation of soluble RhoA and Rac1 and not membrane-bound RhoA and Rac1.
RhoA Binding (bound) of Rac1
3) Confidence 0.21 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.11 Pain Relevance 0
Equal amounts of cell lysate (a, d) were analyzed for relative levels of active RhoA (b) and active Rac1 (e) associated with the membranes (white bar set as 100%) and relative soluble levels of active RhoA (c) and active Rac1 (f) (black bar set as 100%).
RhoA Binding (associated) of Rac1 in bar
4) Confidence 0.21 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.49 Pain Relevance 0
These data suggest that the role of Vav1 in thymic lymphomagenesis could be linked to dysfunctions in its direct downstream targets Rac1 and/or RhoA.
RhoA Binding (/) of Rac1
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.67 Pain Relevance 0

General Comments

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