INT28885

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.53
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tk1) kinase activity (Tk1) cytoplasm (Tk1)
Anatomy Link Frequency
liver 1
follicle 1
uterine 1
lobe 1
Tk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 9 99.08 Very High Very High Very High
Dismenorea 2 98.24 Very High Very High Very High
antagonist 2 66.48 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 3 2 98.88 Very High Very High Very High
Reprotox - General 1 4 98.24 Very High Very High Very High
Necrosis 5 97.48 Very High Very High Very High
Gynecological Disease 2 96.76 Very High Very High Very High
Injury 11 93.84 High High
Body Weight 10 87.84 High High
Hypoalbuminemia 2 86.60 High High
Hematological Disease 4 85.92 High High
Liver Failure 3 83.76 Quite High
Coma 1 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In prostate, BrdU-immunoreactive (S-phase) cells, and TS and TK mRNA expression levels were markedly affected by a zinc deficiency.
Regulation (affected) of TK mRNA
1) Confidence 0.47 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.29 Pain Relevance 0
Zinc appears to regulate TK mRNA through zinc-dependent protein binding to the promoter region of the gene [8].
Spec (appears) Regulation (regulate) of TK mRNA
2) Confidence 0.34 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.23 Pain Relevance 0
The doses of dimethyl disulfide and octanoic acid required for these depressant effects on TK activity were less than half those required for similar effects previously reported after two-lobe hepatectomy of normal rat liver.
Regulation (effects) of TK in lobe
3) Confidence 0.20 Published 1985 Journal J. Lab. Clin. Med. Section Abstract Doc Link 4056569 Disease Relevance 0.52 Pain Relevance 0.29
After partial hepatectomy, TK activity was similarly depressed by the large transient amounts of ammonia but was less affected by the persistent smaller amounts.
Regulation (affected) of TK
4) Confidence 0.18 Published 1989 Journal J. Lab. Clin. Med. Section Abstract Doc Link 2809396 Disease Relevance 0.40 Pain Relevance 0.15
The time sequence of changes in liver ornithine decarboxylase (ODC) activity, which reflects the earliest phases of cell multiplication, liver thymidine kinase (TK) activity, which reflects DNA synthesis, and liver histology (necrosis, mitosis, and repair processes) was recorded.
Regulation (changes) of TK in liver associated with necrosis
5) Confidence 0.17 Published 1985 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3989355 Disease Relevance 0.41 Pain Relevance 0.17
In the present study, the effects of TJ-25 on plasma levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol (E2), and on uterine wet weight and thymidine kinase (TK) activity were documented in immature rats.
Regulation (effects) of TK in follicle
6) Confidence 0.14 Published 1988 Journal J Ethnopharmacol Section Abstract Doc Link 3143030 Disease Relevance 0.39 Pain Relevance 0.10
Thirty hours after administration of E2 (1.0 micrograms/kg) alone, uterine wet weight and TK activity were elevated 2.4- and 21-fold, respectively, over controls.
Regulation (controls) of TK in uterine
7) Confidence 0.09 Published 1988 Journal J Ethnopharmacol Section Abstract Doc Link 3143030 Disease Relevance 0.29 Pain Relevance 0.11

General Comments

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