INT288858

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.41
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HCAR2) signal transducer activity (HCAR2)
Anatomy Link Frequency
epidermal cells 1
HCAR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 88.36 High High
Bile 38 46.96 Quite Low
Pain 4 13.12 Low Low
cva 14 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
nud 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 6 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 323 96.16 Very High Very High Very High
Insulin Resistance 3 87.76 High High
Increased Venous Pressure Under Development 66 75.88 Quite High
Cardiovascular Disease 32 61.92 Quite High
Pressure And Volume Under Development 8 60.84 Quite High
Dyslipidemia /

Combined Dyslipidemia

37 58.64 Quite High
Death 24 57.92 Quite High
Coronary Artery Disease 166 47.68 Quite Low
Rhabdomyolysis 6 15.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism by which niacin affects plasma lipids is not completely understood.16 Niacin binds to a specific G-protein receptor (GPR109A) which is expressed in adipose tissue and in epidermal cells.17 The binding of niacin to the receptor results in a decreased lipolysis and thus a dose-dependent decreased release of free fatty acids into plasma.
Gene_expression (expressed) of GPR109A in epidermal cells associated with obesity
1) Confidence 0.66 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.26 Pain Relevance 0
While the molecular mechanism of niacin’s effect is not known, a G protein–coupled receptor called GPR109A (HM74A) has been identified as a niacin receptor.
Gene_expression (called) of HM74A
2) Confidence 0.54 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.05 Pain Relevance 0.09
While the molecular mechanism of niacin’s effect is not known, a G protein–coupled receptor called GPR109A (HM74A) has been identified as a niacin receptor.
Gene_expression (called) of GPR109A
3) Confidence 0.54 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.05 Pain Relevance 0.09

General Comments

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