INT28886

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Context Info
Confidence 0.45
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.66
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tk1) kinase activity (Tk1) cytoplasm (Tk1)
Anatomy Link Frequency
blood 2
liver 1
Uterine 1
body 1
Tk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 8 97.94 Very High Very High Very High
Dismenorea 1 82.08 Quite High
antagonist 1 45.44 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 12 99.52 Very High Very High Very High
Liver Failure 3 98.62 Very High Very High Very High
Body Weight 5 97.84 Very High Very High Very High
Reprotox - General 3 1 82.72 Quite High
Reprotox - General 1 2 82.08 Quite High
Gynecological Disease 1 80.60 Quite High
Necrosis 1 75.00 Quite High
Hypoalbuminemia 1 69.68 Quite High
Hematological Disease 2 69.00 Quite High
Coma 1 42.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in TK activity occurred before a decline in food intake or body weight, and therefore was not associated with decreased nutrient availability.
Negative_regulation (decrease) of TK in body associated with body weight
1) Confidence 0.45 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.24 Pain Relevance 0
After massive liver injury with acetaminophen, subcoma doses of hepatic failure toxins (NH+4, dimethyl disulfide [----methanethiol], octanoic acid) depressed liver thymidine kinase (TK) activity by 78%, 85%, and 90%, respectively, and ornithine decarboxylase (ODC) activity by 40%, 83%, and 78%, respectively.
Negative_regulation (depressed) of TK in liver associated with liver failure, paracetamol and injury
2) Confidence 0.32 Published 1985 Journal J. Lab. Clin. Med. Section Abstract Doc Link 4056569 Disease Relevance 0.35 Pain Relevance 0.22
Uterine wet weight and TK activity were reduced to 65% and 64% that of controls, respectively.
Negative_regulation (reduced) of TK in Uterine
3) Confidence 0.19 Published 1988 Journal J Ethnopharmacol Section Abstract Doc Link 3143030 Disease Relevance 0.33 Pain Relevance 0.08
Persistent slight or modest increments in blood ammonia level resulting from continuous intravenous infusion of NH4+ depressed hepatic thymidine kinase (TK) activity (DNA synthesis) by 30% after two-lobe (70%) hepatectomy, by 32% after subtotal (90%) hepatectomy, by 80% after massive injury with 1400 mg/kg acetaminophen, and by 92% after massive injury with 1000 mg/kg galactosamine.
Negative_regulation (depressed) of TK in blood associated with paracetamol and injury
4) Confidence 0.17 Published 1989 Journal J. Lab. Clin. Med. Section Abstract Doc Link 2809396 Disease Relevance 0.31 Pain Relevance 0.16
Intermittent marked but transient increments in blood ammonia level resulted in similar but slightly smaller enzyme reductions after the injuries with the toxins, and a reduction of 92% in TK activity after 70% hepatectomy.
Negative_regulation (reduction) of TK in blood associated with injury
5) Confidence 0.15 Published 1989 Journal J. Lab. Clin. Med. Section Abstract Doc Link 2809396 Disease Relevance 0.43 Pain Relevance 0.17

General Comments

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