INT28888

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.80
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Crhr2) endoplasmic reticulum (Crhr2) plasma membrane (Crhr2)
signal transducer activity (Crhr2)
Anatomy Link Frequency
visceral 2
anterior pituitary 2
colons 1
proximal 1
Crhr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 99.68 Very High Very High Very High
Visceral pain 7 99.16 Very High Very High Very High
antagonist 3 89.48 High High
substance P 5 87.92 High High
Neurotransmitter 1 78.08 Quite High
Pain 3 75.92 Quite High
spastic colon 3 75.00 Quite High
agonist 1 69.40 Quite High
intrathecal 2 44.80 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 26 99.92 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

15 99.68 Very High Very High Very High
Sprains And Strains 2 99.46 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

7 99.16 Very High Very High Very High
Nociception 4 93.52 High High
Pain 1 75.92 Quite High
Functional Bowel Disorder 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, this dual action of CRF was differentiated by selective (in)activation of the CRF1 and CRF2 receptor prior to a visceral pain stimulus.
Positive_regulation (activation) of CRF2 in visceral associated with visceral pain
1) Confidence 0.68 Published 2005 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15916630 Disease Relevance 0.24 Pain Relevance 0.47
These data suggest that peripheral CRF2 receptor activation exerts antinociceptive effects on CRD-induced visceral pain, whereas CRF1 contributes to visceral sensitization.
Positive_regulation (activation) of CRF2 receptor in visceral associated with visceral pain and antinociceptive
2) Confidence 0.48 Published 2005 Journal Peptides Section Abstract Doc Link 15949637 Disease Relevance 0 Pain Relevance 0.30
Corticotrophin-releasing factor mRNA in the PVN and POMC mRNA in the anterior pituitary increased in response to i.p. hypertonic saline, restraint and swim stress but not to cold stress.
Neg (not) Positive_regulation (increased) of Corticotrophin-releasing factor mRNA in anterior pituitary associated with stress
3) Confidence 0.38 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2809478 Disease Relevance 0.46 Pain Relevance 0.04
Control levels of functional CRFR2 were similar between strains but sham WKYs samples had increased CRFR2 in both the proximal (SD: 0.88 +/- 0.21, WKY: 1.8 +/- 0.18, P < 0.001) and distal (SD: 0.18 +/- 0.08, WKY: 0.94 +/- 0.32, P < 0.05) regions.
Positive_regulation (increased) of CRFR2 in proximal associated with sprains and strains
4) Confidence 0.37 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19807869 Disease Relevance 0.60 Pain Relevance 0.07
CRD also caused an increase in the functional isoform of CRFR2 in the distal colon of MS rats with no effect in NS colons.
Positive_regulation (increase) of CRFR2 in colons
5) Confidence 0.31 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.17 Pain Relevance 0.07
Corticotrophin-releasing factor mRNA levels in the parvocellular subdivision of the paraventricular nucleus of the hypothalamus and POMC mRNA levels in the anterior pituitary were significantly increased in the stressed group 4h following injection with RP67580 compared to the stressed group injected with vehicle alone.
Positive_regulation (increased) of Corticotrophin-releasing factor mRNA in anterior pituitary
6) Confidence 0.25 Published 2000 Journal Stress Section Abstract Doc Link 10938582 Disease Relevance 0.30 Pain Relevance 0.20
In contrast, distal CRFR1 and CRFR2 levels were higher in MS rats but were significantly reduced post OF stress.
Positive_regulation (higher) of CRFR2 associated with stress
7) Confidence 0.14 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.29 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox