INT28889

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Context Info
Confidence 0.64
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Crhr2) endoplasmic reticulum (Crhr2) plasma membrane (Crhr2)
signal transducer activity (Crhr2)
Anatomy Link Frequency
nucleus 1
CeLC 1
Crhr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 8 99.66 Very High Very High Very High
Pain 5 96.08 Very High Very High Very High
depression 1 82.44 Quite High
antagonist 3 67.12 Quite High
Neurotransmitter 1 49.52 Quite Low
Kinase C inhibitor 1 28.40 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 2 99.28 Very High Very High Very High
Pain 3 96.08 Very High Very High Very High
Anxiety Disorder 2 91.16 High High
Depression 1 82.44 Quite High
Stress 7 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study analyzed the effects of CRF on nociceptive processing in CeLC neurons and the contribution of CRF1 and CRF2 receptors and protein kinases A and C.
Transcription (contribution) of CRF2 in CeLC associated with nociception and amygdala
1) Confidence 0.64 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18171711 Disease Relevance 0.78 Pain Relevance 0.66
In-situ hybridization histochemistry was used to measure corticotrophin-releasing factor mRNA and proenkephalin A mRNA in the paraventricular nucleus (PVN), and pro-opiomelanocortin (POMC) mRNA in the anterior pituitary of the rat.
Transcription (measure) of corticotrophin-releasing factor mRNA in nucleus
2) Confidence 0.56 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2809478 Disease Relevance 0.35 Pain Relevance 0

General Comments

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