INT288903

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.47
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PTX3)
Anatomy Link Frequency
visceral 2
PTX3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 3 99.88 Very High Very High Very High
Inflammation 14 99.12 Very High Very High Very High
cytokine 2 85.84 High High
imagery 2 19.92 Low Low
Inflammatory marker 5 12.64 Low Low
ischemia 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 14 99.98 Very High Very High Very High
Cv General 3 Under Development 3 99.88 Very High Very High Very High
INFLAMMATION 18 99.12 Very High Very High Very High
Arteritis 1 99.04 Very High Very High Very High
Myocardial Infarction 28 98.00 Very High Very High Very High
Coronary Artery Disease 21 94.24 High High
Metabolic Syndrome 44 94.04 High High
Atherosclerosis 9 62.04 Quite High
Emergencies 2 57.88 Quite High
Thrombosis 1 55.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have reported that adipocytes induce PTX3 synthesis by secreting various inflammatory cytokines19) Alberti et al.13) have reported that serum PTX3 concentrations were higher in patients with visceral obesity than those with subcutaneous obesity.
Positive_regulation (induce) of Gene_expression (synthesis) of PTX3 in visceral associated with inflammation, obesity and metabolic syndrome
1) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 0.96 Pain Relevance 0.14
Pitavastatin inhibited the expression of pentraxin 3 (PTX3) related to acute inflammation.26 PTX3 is found to be elevated especially in arterial inflammation in patients with unstable angina pectoris, and increased expression of PTX3 has attracted attention as a new effect of pitavastatin.27

Pharmacokinetics of pitavastatin

Positive_regulation (increased) of Gene_expression (expression) of PTX3 associated with angina, arteritis and inflammation
2) Confidence 0.20 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.51 Pain Relevance 0.30

General Comments

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