INT28891

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.23
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) nucleolus (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 3
neutrophils 2
plasma 1
endothelial cells 1
leukocytes 1
Selp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 5 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
Enkephalin 5 99.64 Very High Very High Very High
Inflammation 234 99.40 Very High Very High Very High
Restless leg syndrome 3 99.28 Very High Very High Very High
headache 2 96.72 Very High Very High Very High
withdrawal 15 96.16 Very High Very High Very High
Inflammatory response 7 96.16 Very High Very High Very High
Angina 14 95.72 Very High Very High Very High
Migraine 6 93.64 High High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 3 100.00 Very High Very High Very High
INFLAMMATION 260 99.40 Very High Very High Very High
Increased Venous Pressure Under Development 8 99.28 Very High Very High Very High
Myocardial Infarction 34 97.84 Very High Very High Very High
Headache 8 97.04 Very High Very High Very High
Vasculitis 6 96.84 Very High Very High Very High
Atherosclerosis 60 95.80 Very High Very High Very High
Cv General 3 Under Development 12 95.72 Very High Very High Very High
Adhesions 28 95.28 Very High Very High Very High
Reperfusion Injury 2 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P-selectin is translocated from platelets and endothelial cells to initiate the first step in a sequence of events leading to the adherence of leukocytes, possibly inducing reperfusion injury and the no-reflow phenomenon in acute myocardial infarction (AMI).
Localization (translocated) of P-selectin in leukocytes associated with reperfusion injury and myocardial infarction
1) Confidence 0.60 Published 1998 Journal Angiology Section Abstract Doc Link 9783645 Disease Relevance 0.55 Pain Relevance 0.06
Repeated exercise induces release of soluble P-selectin in patients with intermittent claudication.
Localization (release) of P-selectin associated with restless leg syndrome
2) Confidence 0.41 Published 1997 Journal Thromb. Haemost. Section Title Doc Link 9408015 Disease Relevance 0.47 Pain Relevance 0.28
Immunohistochemical localization of nitrotyrosine, iNOS, P-selectin, ICAM and IL-1
Localization (localization) of P-selectin
3) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.15 Pain Relevance 0
Sections were incubated overnight with 1) purified goat polyclonal antibody directed towards P-selectin which reacts with mice; or 2) with purified hamster anti-mouse ICAM-1 (CD54) (1:500 in PBS, w/v) (DBA, Milan, Italy) or 3) with anti-nitrotyrosine rabbit polyclonal antibody (1:500 in PBS, v/v) or 4) with anti-iNOS antibody (1:500 in PBS, v/v) or 5) with anti-IL-1?
Localization (directed) of P-selectin
4) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.05 Pain Relevance 0
NO may directly attenuate the activation of platelet, preventing the expression of P-selectin, secretion of platelet granules, intracellular calcium flux, as well as binding of glycoprotein IIb/IIIa to fibrinogen, but could also result in severe detrimental consequences [50], particularly in hemorrhage developed following CPA treatment.
Localization (secretion) of P-selectin in platelet associated with cva
5) Confidence 0.19 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.29 Pain Relevance 0.07
The effect of clopidogrel cessation on expression of biomarkers: sCD40L, soluble P-selectin and hsCRP was measured right before clopidogrel cessation (day 0), and subsequently at 1, 2, 3 and 4 weeks after drug withdrawal.
Localization (soluble) of P-selectin associated with withdrawal
6) Confidence 0.12 Published 2009 Journal J Thromb Thrombolysis Section Abstract Doc Link PMC2766044 Disease Relevance 0.41 Pain Relevance 0.13
The effect of clopidogrel cessation on expression of biomarkers: sCD40L, soluble P-selectin and hsCRP was measured right before clopidogrel cessation (day 0), and subsequently at 1, 2, 3 and 4 weeks after drug withdrawal.
Localization (measured) of P-selectin associated with withdrawal
7) Confidence 0.12 Published 2009 Journal J Thromb Thrombolysis Section Abstract Doc Link PMC2766044 Disease Relevance 0.41 Pain Relevance 0.13
The levels of platelet-derived microparticles (PDMPs), platelet activation markers (P-selectin, CD63, and PAC-1 on activated platelets), and C-C chemokines (monocyte chemotactic peptide [MCP]-1 and regulated on activation normally T-cell expressed and secreted [RANTES] were measured and compared in patients with acute myocardial infarction (AMI) or stable pectoris angina.
Localization (secreted) of P-selectin in platelets associated with chemokine, heart rate under development, angina and myocardial infarction
8) Confidence 0.07 Published 2002 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 12361207 Disease Relevance 0.82 Pain Relevance 0.25
We measured and compared the ratio of elevated levels of regulated on activation normally T-cell expressed and secreted (RANTES), monocytic chemotactic peptide-1 (MCP-1), soluble (s) P-selectin and sL-selectin after PCI.
Localization (secreted) of P-selectin in T-cell
9) Confidence 0.03 Published 2006 Journal Platelets Section Abstract Doc Link 17127484 Disease Relevance 0.60 Pain Relevance 0.21
Chello et al. demonstrated a decrease in P-selectin release from the endothelium and CD11b release from neutrophils after CABG with statin treatment, which in turn inhibits the adhesion of activated neutrophils to the vascular endothelium [21].
Localization (release) of P-selectin in neutrophils associated with adhesions
10) Confidence 0.02 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2927584 Disease Relevance 0.75 Pain Relevance 0.16
Activated platelets interact with neutrophils and endothelial cells and through the release of P-selectin and other pro-inflammatory agents facilitate participation of immune cells in vascular inflammation and atherogenesis [65].
Localization (release) of P-selectin in neutrophils associated with inflammation, atherosclerosis and vasculitis
11) Confidence 0.02 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847313 Disease Relevance 1.58 Pain Relevance 0.21
Activated platelets interact with neutrophils and endothelial cells and through the release of P-selectin and other pro-inflammatory agents facilitate participation of immune cells in vascular inflammation and atherogenesis [65].
Localization (release) of P-selectin in endothelial cells associated with inflammation, atherosclerosis and vasculitis
12) Confidence 0.01 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847313 Disease Relevance 1.58 Pain Relevance 0.21
Plasma-induced release of platelet-serotonin and Met-enkephalin was studied by incubating platelets from migraineurs, tension headache patients and healthy volunteers with water, plasma collected during migraine attacks and with plasma collected during attack-free periods.
Localization (release) of platelet-serotonin in plasma associated with migraine, headache, enkephalin and serotonin
13) Confidence 0.00 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2809630 Disease Relevance 0.57 Pain Relevance 1.12
Interestingly, platelet TXB(2) release during aggregation was enhanced after coxib treatment following arachidonic acid or collagen stimulation.
Localization (release) of platelet TXB in platelet
14) Confidence 0.00 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17916229 Disease Relevance 0 Pain Relevance 0

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