INT288916

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.20
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR1) signal transducer activity (AGTR1)
Anatomy Link Frequency
heart 2
kidney 2
AGTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 92.00 High High
fibrosis 2 91.32 High High
beta blocker 7 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 92.00 High High
Fibrosis 2 91.32 High High
Increased Venous Pressure Under Development 3 90.44 High High
Heart Rate Under Development 19 89.64 High High
Apoptosis 1 74.92 Quite High
Hypertrophy 7 73.96 Quite High
Myocardial Infarction 88 70.40 Quite High
Atherosclerosis 3 68.24 Quite High
Pressure And Volume Under Development 30 68.12 Quite High
Renal Disease 36 59.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients taking ACE-inhibitors, the blunted production of angiotensin II and the consequent reduced stimulation of AT1- and AT2 receptor may induce an ‘escape phenomenon’, which consists in the accumulation of angiotensin I and production of angiotensin II through alternative synthetic bio-pathways (cathepsine C, chimases).10 This phenomenon, well described in patients with congestive heart failure, may be prognostically important.
Negative_regulation (reduced) of Positive_regulation (stimulation) of AT1 in heart associated with heart rate under development
1) Confidence 0.44 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.97 Pain Relevance 0.13
However, ACEIs and ARBs are associated with a feedback loop that increases PRA, as loss of stimulation of AT1 receptors on juxtaglomerular cells in the kidney (ie, removal of negative feedback) leads to a compensatory increase in renin release.
Negative_regulation (loss) of Positive_regulation (stimulation) of AT1 in kidney
2) Confidence 0.16 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.23 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox