INT28893

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.27
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Atp5o)
Anatomy Link Frequency
tail 1
Atp5o (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 28 100.00 Very High Very High Very High
Antihyperalgesic 10 99.74 Very High Very High Very High
diclofenac 6 99.44 Very High Very High Very High
antinociception 14 99.40 Very High Very High Very High
tail-flick 10 99.40 Very High Very High Very High
Antinociceptive 19 98.34 Very High Very High Very High
antagonist 5 89.68 High High
agonist 2 82.88 Quite High
withdrawal 7 73.72 Quite High
Hyperalgesia 4 60.84 Quite High
Disease Link Frequency Relevance Heat
Nociception 4 90.00 High High
Hyperalgesia 12 60.84 Quite High
INFLAMMATION 48 57.60 Quite High
Inflammatory Pain 8 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Relapsing Polychondritis 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mecamylamine, 0.8 nmol coadministered with nicotine, antagonized nicotine antinociception as evidenced by 5- to 8-fold increases in the nicotine A5O.
Positive_regulation (increases) of A5O associated with antinociception and nicotine
1) Confidence 0.43 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2810106 Disease Relevance 0.09 Pain Relevance 1.19
One hour preinjection into the mesopontine tegmentum with 13.5 nmol of (-)-vesamicol, an agent which interferes with acetylcholine storage and/or release, markedly inhibited nicotine antinociception; only a 24% antinociceptive response could be elicited by nicotine in the hot-plate test whereas the nicotine A5O was increased 3-fold in the tail-flick test.
Positive_regulation (increased) of A5O in tail associated with antinociception, nicotine, tail-flick and antinociceptive
2) Confidence 0.43 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2810106 Disease Relevance 0.06 Pain Relevance 1.29
Data show that the antihyperalgesic activity of oATP is significantly more elevated than that of diclofenac and indomethacin.


Positive_regulation (elevated) of oATP associated with antihyperalgesic and diclofenac
3) Confidence 0.02 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.12 Pain Relevance 0.41

General Comments

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