INT28894

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Context Info
Confidence 0.50
First Reported 1989
Last Reported 2007
Negated 3
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.77
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLK2) cytoskeleton (PLK2) intracellular (PLK2)
cytoplasm (PLK2) signal transducer activity (PLK2)
Anatomy Link Frequency
joint 1
muscle 1
legs 1
PLK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
corticosteroid 1 99.48 Very High Very High Very High
Inflammation 2 97.36 Very High Very High Very High
headache 2 94.68 High High
pruritus 2 94.16 High High
Crohn's disease 1 86.32 High High
abdominal pain 1 83.72 Quite High
Disease Link Frequency Relevance Heat
Pain 10 100.00 Very High Very High Very High
Arthralgia 6 99.82 Very High Very High Very High
Myositis 4 98.80 Very High Very High Very High
Muscle Disease 20 98.26 Very High Very High Very High
INFLAMMATION 2 97.36 Very High Very High Very High
Rhabdomyolysis 12 96.84 Very High Very High Very High
Myoglobinuria 6 96.08 Very High Very High Very High
Headache 2 94.68 High High
Eosinophilia 1 94.28 High High
Pruritus 2 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After one year of corticosteroid treatment he experienced increasing pain in both legs and fluctuating serum creatinine kinase levels.
Positive_regulation (increasing) of serum creatinine kinase in legs associated with pain and corticosteroid
1) Confidence 0.50 Published 1989 Journal J. Rheumatol. Section Abstract Doc Link 2810263 Disease Relevance 0.97 Pain Relevance 0.29
The electromyography (EMG) was normal, the serum creatinine-kinase (CK) activity has not increased.
Neg (not) Positive_regulation (increased) of serum creatinine-kinase
2) Confidence 0.48 Published 1994 Journal Orv Hetil Section Abstract Doc Link 8015822 Disease Relevance 0.66 Pain Relevance 0.27
Statin-related skeletal muscle disorders range from benign myalgias – such as non-specific muscle aches or joint pains without elevated serum creatinine kinase (CK) concentration – to true myositis with >10-fold elevation of serum CK [3].
Neg (without) Positive_regulation (elevated) of serum creatinine kinase in muscle associated with pain, arthralgia, muscle disease and myositis
3) Confidence 0.04 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1832194 Disease Relevance 1.32 Pain Relevance 0.14
Statin-related skeletal muscle disorders range from benign myalgias – such as non-specific muscle aches or joint pains without elevated serum creatinine kinase (CK) concentration – to true myositis with >10-fold elevation of serum CK, to rhabdomyolysis and myoglobinuria.
Neg (without) Positive_regulation (elevated) of serum creatinine kinase in joint associated with pain, arthralgia, myoglobinuria, rhabdomyolysis, muscle disease and myositis
4) Confidence 0.02 Published 2007 Journal Lipids Health Dis Section Abstract Doc Link PMC1832194 Disease Relevance 0.82 Pain Relevance 0

General Comments

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