INT2890

Context Info Confidence 0.70 First Reported 1978 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 39 Total Number 39 Disease Relevance 29.58 Pain Relevance 6.01

transport (MB)

Anatomy Link Frequency urine 3 plasma 2 muscle 2 chest 2 lower limbs 1 MB (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 179 99.56 headache 1 98.84 Pain 40 98.82 backache 3 98.20 anesthesia 25 95.88 amygdala 2 95.56 epidural 5 95.44 Periaqueductal grey 1 94.88 Piles 2 94.40 ischemia 120 92.08

Disease Link Frequency Relevance Heat Disorders Of Creatine Metabolism 29 100.00 Rhabdomyolysis 127 99.92 Injury 96 99.92 Ulcers 4 99.88 Myoglobinuria 7 99.84 Acid Base Imbalance 4 99.80 Angina 154 99.56 Renal Failure 38 99.54 Myalgia 14 99.44 Myocardial Infarction 216 99.38

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increase in serum potassium and myoglobin and metabolic acidosis were reported to occur after revascularization.

Positive_regulation (Increase) of myoglobin associated with acid base imbalance

1) Confidence 0.70 Published 1997 Journal Masui Section Abstract Doc Link 9311211 Disease Relevance 0.74 Pain Relevance 0.50

Macromyoglobinuria was noted, and creatine kinase and myoglobin were elevated: 87,800 IU/l and 144,300 ng/ml, respectively.

Positive_regulation (elevated) of myoglobin

2) Confidence 0.67 Published 2004 Journal VASA Section Abstract Doc Link 15224462 Disease Relevance 0.50 Pain Relevance 0.20

Although it is well-known that glycerin enema could cause hemolysis, renal failure and rectal ulcer, the increase of CPK and myoglobin in serum made the diagnosis difficult from other conditions leading to rhabdomyolysis in this case.

Positive_regulation (increase) of myoglobin associated with renal failure, rhabdomyolysis, ulcers and hemolysis

3) Confidence 0.67 Published 2007 Journal Masui Section Abstract Doc Link 17571610 Disease Relevance 1.08 Pain Relevance 0.20

Serum creatinine kinase and myoglobin levels were elevated.

Positive_regulation (elevated) of myoglobin

4) Confidence 0.67 Published 2008 Journal Clin Nucl Med Section Abstract Doc Link 18097264 Disease Relevance 0.72 Pain Relevance 0.10

Laboratory findings showed increased CPK, myoglobin and plasma creatinine levels with acute renal failure.

Positive_regulation (increased) of myoglobin in plasma associated with acute renal failure

5) Confidence 0.65 Published 2010 Journal G Ital Nefrol Section Abstract Doc Link 20672239 Disease Relevance 0.88 Pain Relevance 0.20

At the time of admission, both patients revealed weakness in the proximal muscles of their upper and lower limbs and the serum creatine kinase and myoglobin levels were remarkably elevated.

Positive_regulation (elevated) of myoglobin in upper

6) Confidence 0.62 Published 1992 Journal Rinsho Shinkeigaku Section Abstract Doc Link 1291164 Disease Relevance 0.87 Pain Relevance 0.09

Qualitative bedside assay of increased human serum myoglobin by sandwich dot-immunogold filtration for the diagnosis of acute myocardial infarction.

Positive_regulation (increased) of myoglobin associated with myocardial infarction

7) Confidence 0.62 Published 1998 Journal Clin. Chim. Acta Section Title Doc Link 9657343 Disease Relevance 0.33 Pain Relevance 0.09

INVESTIGATIONS: The myoglobin concentration was dramatically increased in both cases (> 15 000 mg/l).

Positive_regulation (increased) of myoglobin

8) Confidence 0.59 Published 2002 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 12444563 Disease Relevance 0 Pain Relevance 0

Laboratory data showed significant increase of serum CK, aldolase and myoglobin.

Positive_regulation (increase) of myoglobin

9) Confidence 0.57 Published 1990 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2331815 Disease Relevance 0.55 Pain Relevance 0.03

Elevation in serum myoglobin and glutamic pyruvic transaminase and decline in arterial ketone body ratio were also detected.

Positive_regulation (Elevation) of myoglobin in body

10) Confidence 0.53 Published 1996 Journal Masui Section Abstract Doc Link 8725600 Disease Relevance 0.78 Pain Relevance 0.31

His laboratory findings showed abnormally elevated serum creatine phosphokinase and myoglobin but normal thyroid hormone levels.

Positive_regulation (elevated) of myoglobin in thyroid associated with disorders of creatine metabolism

11) Confidence 0.49 Published 2001 Journal Endocr. J. Section Abstract Doc Link 11456272 Disease Relevance 1.10 Pain Relevance 0.29

Histological examination of this mediastinal mass revealed a thymolipoma containing numerous polygonal, striated myoid cells that were immunoreactive for desmin, muscle-specific actin and myoglobin.

Positive_regulation (immunoreactive) of myoglobin in muscle

12) Confidence 0.49 Published 2007 Journal Tumori Section Abstract Doc Link 17557569 Disease Relevance 0.48 Pain Relevance 0.09

Thirty-two patients with myocardial infarction initially examined within 12 hours of the onset of chest pain all showed clear-cut elevations in serum myoglobin, peak values ranging from 200 to 5500 and averaging 1368 +/- 1357 ng/ml.

Positive_regulation (elevations) of myoglobin in chest associated with angina and myocardial infarction

13) Confidence 0.47 Published 1978 Journal Circulation Section Abstract Doc Link 562727 Disease Relevance 0.77 Pain Relevance 0.40

INVESTIGATIONS: Creatinekinase activity (4442 U/l) and myoglobin concentration (3250 micrograms/l) were greatly increased, while creatine (96 mumol/l) and C-reactive protein (22 mg/l) levels were only slightly raised.

Positive_regulation (increased) of myoglobin

14) Confidence 0.46 Published 1997 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 9296927 Disease Relevance 0.19 Pain Relevance 0

We suspected not only hemolysis by the color of the serum and the blood chemistry, but also rhabdomyolysis by increased levels of serum creatine phosphokinase and myoglobin as well as urine myoglobin.

Positive_regulation (increased) of myoglobin in urine associated with disorders of creatine metabolism, rhabdomyolysis and hemolysis

15) Confidence 0.46 Published 2010 Journal Masui Section Abstract Doc Link 20662298 Disease Relevance 1.19 Pain Relevance 0.32

Although serum CPK and myoglobin increased, there was no apparent symptom that supported the onset of rhabdomyolysis induced by anesthetics, acute myocardial infarction or malignant hyperthermia.

Positive_regulation (increased) of myoglobin associated with rhabdomyolysis, malignant hyperthermia and myocardial infarction

16) Confidence 0.45 Published 2007 Journal Masui Section Abstract Doc Link 17571610 Disease Relevance 0.82 Pain Relevance 0.30

Elevation in temperature, white blood cell count, serum muscle enzymes, and urine myoglobin, as well as computer tomographic evidence of paraspinal muscle edema and necrosis, were present.

Positive_regulation (Elevation) of myoglobin in urine associated with necrosis and pressure and volume under development

17) Confidence 0.41 Published 1985 Journal Spine Section Abstract Doc Link 2935950 Disease Relevance 0.61 Pain Relevance 0.10

We suspected not only hemolysis by the color of the serum and the blood chemistry, but also rhabdomyolysis by increased levels of serum creatine phosphokinase and myoglobin as well as urine myoglobin.

Positive_regulation (increased) of myoglobin in urine associated with disorders of creatine metabolism, rhabdomyolysis and hemolysis

18) Confidence 0.40 Published 2010 Journal Masui Section Abstract Doc Link 20662298 Disease Relevance 1.21 Pain Relevance 0.33

Serum creatinine phosphokinase level was mildly elevated at 899 IU/liter with normal myoglobin (MB) fraction level.

Positive_regulation (elevated) of myoglobin

19) Confidence 0.36 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2546416 Disease Relevance 1.08 Pain Relevance 0.12

The concentrations of lactate dehydrogenase (LDH), creatine kinase (CK), and myoglobin were significantly elevated 2, 3, and 4 d postinjury and returned to baseline levels by day 7.

Positive_regulation (elevated) of myoglobin

20) Confidence 0.34 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11557312 Disease Relevance 1.30 Pain Relevance 0.27

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