INT289044

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 0.23
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 3
oocytes 2
Sat2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 44 88.88 High High
Neurotransmitter 88 58.76 Quite High
Glutamate 242 31.64 Quite Low
imagery 11 18.28 Low Low
addiction 33 16.36 Low Low
gABA 44 5.00 Very Low Very Low Very Low
Glutamate receptor 33 5.00 Very Low Very Low Very Low
excitatory amino acid 22 5.00 Very Low Very Low Very Low
tetrodotoxin 11 5.00 Very Low Very Low Very Low
Hippocampus 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 22 94.20 High High
Decapitation 11 5.00 Very Low Very Low Very Low
Starvation 11 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SLC38A1 transporter protein (SAT1) is expressed mainly in neurons (Varoqui et al., 2000; Wang et al., 2000; Chaudhry et al., 2002b; Mackenzie et al., 2003; Melone et al., 2004; Buntup et al., 2008) whereas the SLC38A2 protein (SAT2) is expressed in many tissues, including neurons and potentially in glia (Reimer et al., 2000; Sugawara et al., 2000a; Yao et al., 2000; Gonzalez-Gonzalez et al., 2005; Melone et al., 2006; Jenstad et al., 2009).
Gene_expression (expressed) of SAT2 in neurons
1) Confidence 0.58 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0 Pain Relevance 0.03
The MeAIB induced current is 34% of the magnitude of Igln, which is very similar to the relative MeAIB current observed in Xenopus oocytes expressing SAT1 (Chaudhry et al., 2002b) or SAT2 (Reimer et al., 2000; Sugawara et al., 2000a; Yao et al., 2000).
Gene_expression (expressing) of SAT2 in oocytes
2) Confidence 0.58 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0 Pain Relevance 0
The magnitude of the proline current and intermediate glutamine affinity are consistent with a mixture of SAT1 and SAT2 currents in our recordings.
Gene_expression (currents) of SAT2
3) Confidence 0.51 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0 Pain Relevance 0.04
Two isoforms of the system A transporters have been proposed to be present in neurons, SAT1 and SAT2.
Gene_expression (neurons) of SAT2 in neurons
4) Confidence 0.51 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0 Pain Relevance 0
SAT1 and SAT2 antibodies (as above) were used at 0.5 and 0.25 ?
Gene_expression (antibodies) of SAT2
5) Confidence 0.51 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0.09 Pain Relevance 0
Two isoforms of the system A transporters have been proposed to be present in neurons, SAT1 and SAT2.
Gene_expression (present) of SAT2 in neurons
6) Confidence 0.51 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0 Pain Relevance 0
This finding is supported by our electrophysiological data, which show a proline response that is neither significantly greater (as expected for SAT2) nor significantly smaller (as for SAT1) than the glutamine response.
Neg (neither) Gene_expression (expected) of SAT2
7) Confidence 0.51 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0 Pain Relevance 0.04
g/ml, while SAT2 was used at a concentration of 10 ?
Gene_expression (used) of SAT2
8) Confidence 0.51 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0.08 Pain Relevance 0
SAT1 and SAT2 proteins are expressed in the MNTB
Gene_expression (expressed) of SAT2
9) Confidence 0.45 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0.05 Pain Relevance 0
Glutamine transporter expression in the CNS has been observed for system A isoforms SAT1 (also called SA2, SNAT1, NAT2, GlnT and ATA1: Varoqui et al., 2000; Wang et al., 2000; Chaudhry et al., 2002b; Melone et al., 2004) and SAT2 (also called SA1, SNAT2 and ATA2: Reimer et al., 2000; Sugawara et al., 2000a; Yao et al., 2000; Gonzalez-Gonzalez et al., 2005; Melone et al., 2006; Jenstad et al., 2009); system ASC (ASCT2: Broer et al., 1999; Dolinska et al., 2004; Yamamoto et al., 2004); system B0 (B0AT2: Inoue et al., 1996; Takanaga et al., 2005; Broer et al., 2006); system B0,+ (ATB0,+: Sloan and Mager, 1999); system b0,+ (rBAT/b0,+AT: Bertran et al., 1992; Tate et al., 1992; Wells and Hediger, 1992); system L (LAT1 and LAT2: Kanai et al., 1998; Rossier et al., 1999; Segawa et al., 1999); system N (SN1/SNAT3 and SN2/SNAT5: Chaudhry et al., 1999, 2001; Nakanishi et al., 2001; Boulland et al., 2002, 2003; Cubelos et al., 2005) and system y+L (y+LAT2: Broer et al., 2000).
Gene_expression (expression) of SAT2
10) Confidence 0.45 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0 Pain Relevance 0.06
In addition, we observe a Km for glutamine of 0.94±0.25 mM, which lies in between the Kms observed for SAT1 (0.3–0.4 mM) and SAT2 (1.7–2.3 mM) when expressed in Xenopus oocytes (Yao et al., 2000; Chaudhry et al., 2002b; Mackenzie et al., 2003).
Gene_expression (expressed) of SAT2 in oocytes
11) Confidence 0.44 Published 2009 Journal Neuroscience Section Body Doc Link PMC2789247 Disease Relevance 0 Pain Relevance 0.04

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