INT289101

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.58
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) DNA binding (LEF1) cytoplasm (LEF1)
transmembrane transport (KCNA1) cell adhesion (LEF1) plasma membrane (KCNA1)
Anatomy Link Frequency
SW480 1
KCNA1 (Homo sapiens)
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 12 66.28 Quite High
addiction 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 304 99.84 Very High Very High Very High
Cancer 28 99.52 Very High Very High Very High
Colon Cancer 12 98.68 Very High Very High Very High
Death 20 91.80 High High
Apoptosis 88 80.48 Quite High
Toxicity 12 80.24 Quite High
Malignant Neoplastic Disease 16 75.56 Quite High
Stress 20 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immune co-precipitation experiments demonstrated that EA could directly bind to LEF-1 protein and destabilize the LEF-1/?
EA Binding (bind) of LEF-1 protein
1) Confidence 0.00 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2789382 Disease Relevance 1.10 Pain Relevance 0
Instead, EA directly interacted with LEF-1, and induced the destabilization of the LEF-1/?
EA Binding (interacted) of LEF
2) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.40 Pain Relevance 0.03
To test whether EA could similarly interact with LEF-1 in other tumor cells, a human colon cancer cell line SW480 was tested.
EA Binding (interact) of LEF in SW480 associated with cancer and colon cancer
3) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.53 Pain Relevance 0
To determine whether EA could indeed directly interact with LEF-1, CLL cells that had been treated with the drug were lysed, immunoprecipitated with anti-LEF-1 antibody, and probed in immunoblots using the anti-EA antibody (Figure 4A).
EA Binding (interact) of LEF associated with chronic lymphoid leukemia
4) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.56 Pain Relevance 0

General Comments

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