INT289116

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.19
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) cell adhesion (LEF1) nucleus (LEF1)
DNA binding (LEF1) transcription factor binding (LEF1) cytoplasm (LEF1)
Anatomy Link Frequency
nucleus 2
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 2 82.72 Quite High
aspirin 7 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 76 94.08 High High
Stress 6 90.24 High High
Colon Cancer 6 88.56 High High
Death 5 87.60 High High
Cancer 20 71.04 Quite High
Adenocarcinoma 1 54.80 Quite High
Adenoma 1 54.04 Quite High
Toxicity 3 50.00 Quite Low
Apoptosis 25 40.68 Quite Low
Malignant Neoplastic Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin accumulates in the nucleus, Groucho/TLE is displaced from Tcf/Lef by ?
Positive_regulation (accumulates) of Localization (displaced) of Lef in nucleus
1) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.17 Pain Relevance 0
3 µM, while the IC50 for EA inhibition of Wnt3A-induced transcription in HEK293 is about 25 µM, and the EA concentration required to destabilize the LEF-1/?
Positive_regulation (required) of Localization (destabilize) of LEF
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 1.03 Pain Relevance 0.04

General Comments

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