INT289127

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) cell adhesion (LEF1) nucleus (LEF1)
DNA binding (LEF1) transcription factor binding (LEF1) cytoplasm (LEF1)
Anatomy Link Frequency
stem cell 1
fin 1
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 14 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 98.40 Very High Very High Very High
Cancer 33 98.20 Very High Very High Very High
Colon Cancer 9 98.08 Very High Very High Very High
Chronic Lymphoid Leukemia 76 88.72 High High
Stress 7 66.72 Quite High
Toxicity 3 50.00 Quite Low
Meningioma 4 43.76 Quite Low
Mouth Cancer 2 33.16 Quite Low
Adhesions 8 22.24 Low Low
Adenoma 2 6.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin at Ser552 by AKT1 increases nuclear translocation and retention, enhancing Tcf4/Lef1 complex transcriptional activity to promote tumor cell invasion and stem cell migration.
Positive_regulation (enhancing) of Lef1 in stem cell associated with cancer
1) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.18 Pain Relevance 0
Further, repression of Lef1 by miR-203 blocks fin regeneration, whereas loss of miR-203 results in excess Lef1 levels and fin overgrowth.


Positive_regulation (excess) of Lef1 in fin associated with repression
2) Confidence 0.20 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.25 Pain Relevance 0
This result suggests that EA may inhibit LEF-1-mediated transcription through destabilization of the LEF-1/?
Positive_regulation (destabilization) of LEF
3) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.34 Pain Relevance 0

General Comments

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