INT28921

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Context Info
Confidence 0.24
First Reported 1989
Last Reported 1989
Negated 0
Speculated 1
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) extracellular region (Prl) plasma membrane (Adra2a)
cytoplasm (Adra2a) signal transducer activity (Adra2a)
Adra2a (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 4 99.74 Very High Very High Very High
narcan 4 98.92 Very High Very High Very High
Intracerebroventricular 4 97.04 Very High Very High Very High
antagonist 4 77.16 Quite High
agonist 2 70.28 Quite High
Clonidine 4 69.88 Quite High
opiate 2 60.48 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the mechanism by which the alpha 2-adrenergic system stimulates PRL release in urethane-anesthetized male rats.
alpha 2-adrenergic Spec (investigated) Positive_regulation (stimulates) of Localization (release) of PRL
1) Confidence 0.24 Published 1989 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2813439 Disease Relevance 0 Pain Relevance 0.28
Possible involvement of endogenous opioid peptides in prolactin secretion induced by alpha 2-adrenergic stimulation in rats.
alpha 2-adrenergic Positive_regulation (induced) of Localization (secretion) of prolactin associated with narcan and endogenous opioid
2) Confidence 0.20 Published 1989 Journal Proc. Soc. Exp. Biol. Med. Section Title Doc Link 2813439 Disease Relevance 0 Pain Relevance 0.62

General Comments

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