INT289237

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.84
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6ra) extracellular region (Il6ra) enzyme binding (Il6ra)
Anatomy Link Frequency
joint 2
SH2 1
osteoblasts 1
Il6ra (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 65 94.80 High High
Arthritis 25 94.60 High High
Inflammation 165 85.40 High High
rheumatoid arthritis 5 50.00 Quite Low
metalloproteinase 5 41.16 Quite Low
chemokine 5 20.56 Low Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
abatacept 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 305 99.72 Very High Very High Very High
Stress 5 99.32 Very High Very High Very High
Synovitis 10 97.28 Very High Very High Very High
Hypercalcemia 30 96.24 Very High Very High Very High
Targeted Disruption 25 95.96 Very High Very High Very High
Disease 75 94.92 High High
Experimental Arthritis 10 94.60 High High
Arthritis 20 91.12 High High
Osteoporosis 45 62.20 Quite High
INFLAMMATION 170 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in IL-6 and sIL-6R in SF increases the risk of joint destruction in RA [11].
Positive_regulation (increase) of sIL-6R in joint associated with rheumatoid arthritis
1) Confidence 0.05 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.76 Pain Relevance 0.14
In an in vitro study, IL-6-induced osteoclast differentiation is indirect and appears to be mediated via interaction with osteoblasts through the sIL-6R, resulting in PGE2 synthesis.
Positive_regulation (mediated) of sIL-6R in osteoblasts
2) Confidence 0.04 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.77 Pain Relevance 0.15
Levels of IL-6 and sIL-6R in SF correlate significantly with local joint measures of chronic synovitis and the severity of joint destruction in patients with RA [60], as does sIL-6R with leucocyte infiltration [61].
Positive_regulation (Levels) of sIL-6R in joint associated with rheumatoid arthritis and synovitis
3) Confidence 0.04 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.98 Pain Relevance 0.03
In IL-6 trans-signalling, sIL-6R is generated either by limited proteolysis of the membrane-bound IL-6R or by alternative mRNA splicing.
Positive_regulation (generated) of sIL-6R
4) Confidence 0.04 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.48 Pain Relevance 0.10
IL-6R stimulation also recruits other signal transduction molecules, including SH2 domain-containing tyrosine phosphatase (SHP2) and suppressor of cytokine signalling (SOCS).
Positive_regulation (stimulation) of IL-6R in SH2 associated with cytokine
5) Confidence 0.04 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.85 Pain Relevance 0.18

General Comments

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