INT289245

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) extracellular space (Il6ra) extracellular region (Il6ra)
plasma membrane (Ptger2) enzyme binding (Il6ra) signal transducer activity (Ptger2)
Anatomy Link Frequency
osteoblasts 3
Il6ra (Mus musculus)
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 5 85.28 High High
Inflammation 33 84.88 Quite High
rheumatoid arthritis 1 50.00 Quite Low
cytokine 13 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 6 95.72 Very High Very High Very High
Arthritis 4 85.28 High High
Rheumatoid Arthritis 61 75.72 Quite High
Disease 15 61.80 Quite High
INFLAMMATION 34 58.40 Quite High
Arthropathy 1 50.72 Quite High
Synovitis 2 34.48 Quite Low
Fatigue 10 5.00 Very Low Very Low Very Low
Anaemia 9 5.00 Very Low Very Low Very Low
Osteoporosis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an in vitro study, IL-6-induced osteoclast differentiation is indirect and appears to be mediated via interaction with osteoblasts through the sIL-6R, resulting in PGE2 synthesis.
sIL-6R Binding (interaction) of in osteoblasts Positive_regulation (resulting) of Gene_expression (synthesis) of PGE2 in osteoblasts
1) Confidence 0.00 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.82 Pain Relevance 0.15

General Comments

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