INT289248

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Il21) extracellular region (Il6, Il21)
Anatomy Link Frequency
B-cell 2
Il6 (Mus musculus)
Il21 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 33 92.36 High High
cytokine 13 77.00 Quite High
rheumatoid arthritis 1 50.00 Quite Low
Arthritis 5 42.80 Quite Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 93.68 High High
INFLAMMATION 34 92.36 High High
Rheumatoid Arthritis 61 89.48 High High
Autoimmune Disease 3 72.08 Quite High
Stress 1 70.12 Quite High
Targeted Disruption 5 44.16 Quite Low
Experimental Arthritis 2 42.80 Quite Low
Arthritis 4 39.32 Quite Low
Fatigue 10 5.00 Very Low Very Low Very Low
Anaemia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 induces B-cell differentiation through its action on plasmablasts [16] and more recently has been shown to induce B-cell antibody production indirectly by promoting the B-cell helper properties of CD4+ T cells via the production of IL-21 [17].
IL-6 Positive_regulation (promoting) of Gene_expression (production) of IL-21 in B-cell
1) Confidence 0.06 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.69 Pain Relevance 0.15

General Comments

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