INT289250

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Il6, Timp1) extracellular space (Il6) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
chondrocytes 2
Il6 (Mus musculus)
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 61.16 Quite High
rheumatoid arthritis 1 50.00 Quite Low
Inflammation 33 43.84 Quite Low
chemokine 1 40.56 Quite Low
cytokine 13 11.80 Low Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 61 93.96 High High
Osteoporosis 9 82.20 Quite High
Synovitis 2 58.56 Quite High
INFLAMMATION 34 43.84 Quite Low
Disease 15 41.76 Quite Low
Arthritis 4 30.08 Quite Low
Targeted Disruption 5 6.64 Low Low
Fatigue 10 5.00 Very Low Very Low Very Low
Anaemia 9 5.00 Very Low Very Low Very Low
Hypercalcemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6, in the presence of sIL-6R, induced TIMP-1 mRNA and protein expression in cultured human chondrocytes and synovial fibroblasts [58].
IL-6 Positive_regulation (induced) of Gene_expression (expression) of TIMP in chondrocytes
1) Confidence 0.11 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.64 Pain Relevance 0.03

General Comments

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