INT289258

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
intracellular (ABCA1) enzyme binding (Il6ra) lipid metabolic process (ABCA1)
ABCA1 (Homo sapiens)
Il6ra (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 13 77.88 Quite High
rheumatoid arthritis 1 50.00 Quite Low
Inflammation 33 43.00 Quite Low
Arthritis 5 15.60 Low Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 1 80.12 Quite High
Plasmacytoma 1 71.72 Quite High
Rheumatoid Arthritis 61 60.08 Quite High
INFLAMMATION 34 43.00 Quite Low
Autoimmune Disease 3 40.16 Quite Low
Disease 15 30.40 Quite Low
Experimental Arthritis 2 16.64 Low Low
Synovitis 2 14.72 Low Low
Fatigue 10 5.00 Very Low Very Low Very Low
Anaemia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated sIL-6R binds to membrane-bound gp130 subunits in a process known as trans-signalling (Fig. 2B) [4, 7]. sIL-6R is generated either by limited proteolysis of the membrane-bound IL-6R or by alternative mRNA splicing. sIL-6R is transported in bodily fluids and increases the variety of cells able to respond to IL-6 [4].
membrane-bound Binding (binds) of sIL-6R
1) Confidence 0.00 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

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