INT289273

Context Info Confidence 0.20 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0

plasma membrane (Cd55)

Anatomy Link Frequency red blood cells 2 Cd55 (Mus musculus)

Pain Link Frequency Relevance Heat cva 7 5.00 headache 4 5.00 rheumatoid arthritis 1 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Paroxysmal Nocturnal Hemoglobinuria 97 99.48 Disease 14 87.76 Hemolysis 29 68.00 Rare Diseases 1 43.92 Thrombosis 25 14.68 Infection 7 5.00 Fatigue 5 5.00 Chronic Renal Failure 5 5.00 Hypertension 4 5.00 Headache 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The absence or reduced expression of CD55 and CD59 on PNH red blood cells leads to their increased sensitivity to complement mediated attack.

Negative_regulation (reduced) of Gene_expression (expression) of CD55 in red blood cells associated with paroxysmal nocturnal hemoglobinuria

1) Confidence 0.20 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789686 Disease Relevance 0.53 Pain Relevance 0

General Comments

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