INT28929

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 16.64
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PVR) extracellular region (PVR) nucleolus (PVR)
plasma membrane (PVR) nucleus (PVR) cytoplasm (PVR)
Anatomy Link Frequency
SVR 2
liver 1
mitral valve 1
blood 1
vasculature 1
PVR (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 17 97.60 Very High Very High Very High
midbrain 6 95.64 Very High Very High Very High
Inflammation 17 95.24 Very High Very High Very High
headache 21 95.04 Very High Very High Very High
adenocard 24 89.76 High High
Paracetamol 47 88.88 High High
Spinal cord 6 84.04 Quite High
imagery 21 81.68 Quite High
addiction 1 81.60 Quite High
cva 135 70.60 Quite High
Disease Link Frequency Relevance Heat
Persistent Vegetative State 405 100.00 Very High Very High Very High
Quadriplegia 3 100.00 Very High Very High Very High
Coma 42 99.76 Very High Very High Very High
Pulmonary Hypertension 2118 99.48 Very High Very High Very High
Polio 56 99.26 Very High Very High Very High
Injury 68 99.24 Very High Very High Very High
Heart Rate Under Development 63 99.20 Very High Very High Very High
Paralysis 10 98.96 Very High Very High Very High
Cv General 4 Under Development 167 96.68 Very High Very High Very High
Brain Ischemia 3 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant decrease of systolic and diastolic BPs, RAP, PCP, SVR and PVR was observed after 1/2 of IS-5-MN administration and was maintained through the study, while CI and CPP increased and HR remained unchanged.
Negative_regulation (decrease) of PVR in PCP
1) Confidence 0.57 Published 1989 Journal Rev Esp Cardiol Section Abstract Doc Link 2813884 Disease Relevance 0.52 Pain Relevance 0.07
Vasodilators administered intravenously may decrease PVR, but they also have longer half lives and affect systemic circulation.
Spec (may) Negative_regulation (decrease) of PVR
2) Confidence 0.45 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.98 Pain Relevance 0.03
It was found that mPAP and PVR decreased by 22% and 40.4% respectively, CI increased significantly, MAP, systemic vascular resistance (SVR) and PaO2 decreased significantly while DO2 and VO2 changed slightly.
Negative_regulation (decreased) of PVR in SVR
3) Confidence 0.42 Published 1993 Journal Zhonghua Nei Ke Za Zhi Section Abstract Doc Link 8112140 Disease Relevance 0.50 Pain Relevance 0.10
Nesiritide acutely and significantly reduced PA pressure, PVR, and biventricular filling pressures in patients with postcapil-lary pulmonary hypertension.
Negative_regulation (reduced) of PVR associated with pulmonary hypertension
4) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.17 Pain Relevance 0
Based on available data, therapy of acute arterial pulmonary hypertension should be generally aimed at acutely relieving RV pressure overload by decreasing PVR and preventing or reversing RV dysfunction with pulmonary vasodilators and inotropes.
Negative_regulation (decreasing) of PVR associated with pulmonary hypertension
5) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.19 Pain Relevance 0
Inhaled nitroglycerin may be a safer therapeutic option leading to a significant reduction in both mean PAP and PVR in patients after mitral valve operations without reducing systemic mean arterial pressure (Yurtseven et al 2003).
Negative_regulation (reduction) of PVR in mitral valve
6) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.87 Pain Relevance 0.08
However, norepeinephrine is superior to phenylephrine in restoring systemic arterial pressure, decreasing PVR, augmenting right ventricular myocardial blood flow and improving cardiac output in animal model of acute PE (Hirsch et al 1991).
Negative_regulation (decreasing) of PVR in blood
7) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.78 Pain Relevance 0
It is rather difficult to outline a common clinical course for these cases but the PVS is usually preceded by a coma with a certain number of these patients (1–14%) their condition develops into a PVS.
Negative_regulation (preceded) of PVS associated with persistent vegetative state and coma
8) Confidence 0.37 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2245970 Disease Relevance 1.47 Pain Relevance 0
However, because in most cases of PVS the connectivity between lower brain areas and cortex is diminished, cortical EEG activity does not show the full range of changes associated with normal sleep.
Negative_regulation (diminished) of PVS in cortex associated with persistent vegetative state
9) Confidence 0.37 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2245970 Disease Relevance 0.63 Pain Relevance 0.05
Such correlates may be sufficient to avoid a misdiagnosis in the strict sense, to distinguish e.g. between a locked in syndrome and a PVS.
Negative_regulation (locked) of PVS associated with persistent vegetative state and quadriplegia
10) Confidence 0.37 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2245970 Disease Relevance 0.49 Pain Relevance 0.07
In the PVR model, baseline PVR level, followed by drug dose, was the most important covariate for the probability that a patient treated for 12 weeks would develop PVR >100 mL.
Negative_regulation (develop) of PVR
11) Confidence 0.34 Published 2010 Journal BMC Urol Section Body Doc Link PMC2939595 Disease Relevance 0 Pain Relevance 0.04
In animal models of both acute and chronic pulmonary hypertension, milrinone significantly reduced PVR and improved RV function (Chen et al 1997; Hashiba et al 2000).
Negative_regulation (reduced) of PVR associated with pulmonary hypertension
12) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.61 Pain Relevance 0
RV dysfunction occurred with volume expansion, despite constant PVR and a decrease in mean PAP.
Negative_regulation (decrease) of PVR
13) Confidence 0.29 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.65 Pain Relevance 0.04
The four categories into which human enteroviruses were subdivided were: (1) polioviruses, which caused flaccid paralysis (poliomyelitis) in humans but not in suckling mice lacking CD155; (2) coxsackie A viruses (CAV), which were linked to human central nervous system (CNS) pathology and skeletal muscle inflammation (myositis) as well as acute flaccid paralysis in suckling mice; (3) coxsackie B viruses (CBV), associated with ailments of the human cardiac and central nervous systems, and necrosis of the fat pads between the shoulders, focal lesions in skeletal muscle, brain, and spinal cord, as well as spastic paralysis in the suckling mouse experimental model; and (4) echoviruses, which were not originally associated with human disease nor with paralysis in mice [41,121,201].
Negative_regulation (lacking) of CD155 in fat pads associated with polio, cerebral palsy, disease, myositis, spinal cord, necrosis, inflammation, central nervous system and paralysis
14) Confidence 0.29 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 1.18 Pain Relevance 0.19
g/kg/min) dobutamine decreased PVR, lowered MAP and slightly increased cardiac output (Bradford et al 2000); at doses of 5–10 ?
Negative_regulation (decreased) of PVR
15) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.72 Pain Relevance 0
The reduction in PVR in this group was similar to that seen in the main analysis but the confidence interval ranged from ?
Negative_regulation (reduction) of PVR
16) Confidence 0.27 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.61 Pain Relevance 0
One report describes a decrease in the ratio of PVR to systemic vascular resistance (SVR) at lower doses, suggesting selectivity for the pulmonary vasculature (Ghofrani et al 2002a).
Negative_regulation (decrease) of PVR in vasculature
17) Confidence 0.22 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 0.43 Pain Relevance 0
There was a trend towards a decrease in PVR in the treatment groups (Aldashev et al 2005).


Negative_regulation (decrease) of PVR
18) Confidence 0.22 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 0.68 Pain Relevance 0
Acute administration of a single oral dose of sildenafil causes a significant decrease in mPAP and PVR with minimal or no affect on mean arterial pressure (MAP) and improvement, or a trend towards improvement, in cardiac output.
Negative_regulation (decrease) of PVR
19) Confidence 0.22 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 0.78 Pain Relevance 0.13
7.9 m for placebo.36 Analysis of PVR values using the Wilcoxon rank-sum test showed a significant decrease in PVR for the bosentan group (83.2% versus placebo 107.5%).36 Other hemodynamic variables that showed improvement were mPAP, CI and mVO2.36 TTCW was delayed with bosentan therapy (p < 0.02) compared with placebo with a hazard ratio of 0.23.36 Twelve patients taking placebo progressed to FC III compared with only 3 patients on bosentan (p < 0.05).
Negative_regulation (decrease) of PVR
20) Confidence 0.19 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.21 Pain Relevance 0

General Comments

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