INT2893

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Context Info
Confidence 0.80
First Reported 1978
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 219
Total Number 221
Disease Relevance 28.96
Pain Relevance 79.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
uterine 16
neurons 9
pituitary 8
neurohypophysis 7
brain 5
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 226 100.00 Very High Very High Very High
Opioid 215 100.00 Very High Very High Very High
Enkephalin 73 100.00 Very High Very High Very High
Neuropeptide 57 100.00 Very High Very High Very High
transdermal 36 100.00 Very High Very High Very High
Catecholamine 22 100.00 Very High Very High Very High
substance P 11 100.00 Very High Very High Very High
Cholecystokinin 9 100.00 Very High Very High Very High
Oxycodone 7 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 161 99.98 Very High Very High Very High
Dysmenorrhea 131 99.92 Very High Very High Very High
Drug Dependence 38 99.92 Very High Very High Very High
Cocaine Dependence 4 99.92 Very High Very High Very High
Heart Rate Under Development 8 99.64 Very High Very High Very High
Hemorrhage 12 99.56 Very High Very High Very High
Natriuresis 21 99.48 Very High Very High Very High
Targeted Disruption 71 99.46 Very High Very High Very High
Hyponatremia 10 99.28 Very High Very High Very High
Nociception 9 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, despite evidence in oxytocin knockout mice that oxytocin is not essential for parturition in this species, the results of the present study indicate that oxytocin neurone activity and secretion contribute to the birth process in normal mice.
Localization (secretion) of oxytocin associated with targeted disruption
1) Confidence 0.80 Published 2002 Journal Reproduction Section Abstract Doc Link 11914117 Disease Relevance 0.41 Pain Relevance 0.50
Morphine inhibits nocturnal oxytocin secretion and uterine contractions in the pregnant baboon.
Localization (secretion) of oxytocin in uterine associated with dismenorea and morphine
2) Confidence 0.80 Published 1998 Journal Biol. Reprod. Section Title Doc Link 9546727 Disease Relevance 0.64 Pain Relevance 1.36
Nipple stimulation has been used to induce labour and our data may suggest that oxytocin released in response to such stimulation is responsible for the contractions induced.
Localization (released) of oxytocin in Nipple
3) Confidence 0.80 Published 1989 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 2618602 Disease Relevance 0.17 Pain Relevance 0.08
During parturition, oxytocin cells increase their basal activity, and hence oxytocin secretion increases.
Localization (secretion) of oxytocin
4) Confidence 0.79 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0.06 Pain Relevance 0.49
Each burst causes the secretion of a pulse of oxytocin, which sharply increases uterine tone; these bursts depend upon auto-stimulation by oxytocin released from the dendrites of the magnocellular neurons in the supraoptic and paraventricular nuclei.
Localization (secretion) of oxytocin in neurons
5) Confidence 0.79 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0 Pain Relevance 0.42
Oxytocin is known to be inhibited by endogenous opioids at parturition, thus future research should consider the potential role of increased nociception at birth as a negative feedback to oxytocin release.
Localization (release) of oxytocin associated with nociception and endogenous opioid
6) Confidence 0.79 Published 1997 Journal Pain Section Abstract Doc Link 9272799 Disease Relevance 0.49 Pain Relevance 0.50
Oxytocin secretion from the posterior pituitary gland is increased during parturition, stimulated by the uterine contractions that forcefully expel the fetuses.
Localization (secretion) of Oxytocin in uterine associated with dismenorea
7) Confidence 0.79 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0.10 Pain Relevance 0.19
Each burst causes the secretion of a pulse of oxytocin, which sharply increases uterine tone; these bursts depend upon auto-stimulation by oxytocin released from the dendrites of the magnocellular neurons in the supraoptic and paraventricular nuclei.
Localization (released) of oxytocin in neurons
8) Confidence 0.79 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0 Pain Relevance 0.41
Most likely, oxytocin can also be released by stimulation of other senses such as olfaction, as well as by certain types of sound and light.
Localization (released) of oxytocin
9) Confidence 0.79 Published 2005 Journal Z Psychosom Med Psychother Section Abstract Doc Link 15834840 Disease Relevance 0.70 Pain Relevance 0.13
Oxytocin can be released by various types of non-noxious sensory stimulation, for example by touch and warmth.
Localization (released) of Oxytocin associated with increased venous pressure under development
10) Confidence 0.79 Published 2005 Journal Z Psychosom Med Psychother Section Abstract Doc Link 15834840 Disease Relevance 0.70 Pain Relevance 0.15
In This Week in Science for 12 June (p. 1495), the first sentence of the item "Uterine oxytocin" should have read, "Oxytocin is a peptide hormone secreted from the posterior pituitary that causes uterine contractions and is used to induce labor."
Localization (secreted) of Oxytocin in Uterine associated with dismenorea
11) Confidence 0.79 Published 1992 Journal Science Section Abstract Doc Link 17835878 Disease Relevance 0.10 Pain Relevance 0.10
Oxytocin is released both peripherally, where it is involved in milk letdown and the facilitation of uterine contractions, and centrally, where it acts as a neuromodulator along with arginine vasopressin.
Localization (released) of Oxytocin in uterine associated with dismenorea
12) Confidence 0.79 Published 2010 Journal Neurotherapeutics Section Abstract Doc Link 20643377 Disease Relevance 0.40 Pain Relevance 0.14
The activity of opiate-mediated regulatory mechanisms of oxytocin secretion during breast-feeding was studied by the administration of either morphine, naloxone or placebo to women prior to the commencement of breast-feeding.
Localization (secretion) of oxytocin associated with narcan, opiate and morphine
13) Confidence 0.79 Published 1999 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 10394089 Disease Relevance 0 Pain Relevance 0.44
In conclusion, oxytocin secretion to breast-feeding is inhibited by exogenous morphine when compared to a control group but the administration of naloxone did not produce a significant difference from control.
Localization (secretion) of oxytocin associated with narcan and morphine
14) Confidence 0.79 Published 1999 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 10394089 Disease Relevance 0 Pain Relevance 0.78
Boar contact does not induce oxytocin release during the period of embryo migration in sows.
Localization (release) of oxytocin in embryo
15) Confidence 0.79 Published 2006 Journal Reprod. Domest. Anim. Section Title Doc Link 16689888 Disease Relevance 0.09 Pain Relevance 0.09
To test the hypothesis that oxytocin secretion is regulated by endogenous opioids in the periparturient period, we have 1) characterized oxytocin secretion in response to vaginocervical stimulation and 2) determined the effect of naloxone, an opioid antagonist, on oxytocin secretion induced by vaginocervical stimulation in prepartum mares and in postpartum mares at estrus and diestrus.
Localization (secretion) of oxytocin associated with antagonist, narcan, endogenous opioid and opioid
16) Confidence 0.79 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.33
To test the hypothesis that oxytocin secretion is regulated by endogenous opioids in the periparturient period, we have 1) characterized oxytocin secretion in response to vaginocervical stimulation and 2) determined the effect of naloxone, an opioid antagonist, on oxytocin secretion induced by vaginocervical stimulation in prepartum mares and in postpartum mares at estrus and diestrus.
Localization (secretion) of oxytocin associated with antagonist, narcan, endogenous opioid and opioid
17) Confidence 0.79 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.31
The effect of epidural analgesia on oxytocin release during the second stage of normal labour was studied by comparing 10 primigravidae who had epidurals with 10 control subjects who did not have epidurals.
Localization (release) of oxytocin associated with epidural and analgesia
18) Confidence 0.79 Published 1983 Journal Br J Obstet Gynaecol Section Abstract Doc Link 6830729 Disease Relevance 0 Pain Relevance 0.36
During the postpartum period, total amount of oxytocin secreted following vaginocervical stimulation tended to be greater than during the prepartum period, and stimulated oxytocin secretion was significantly greater in naloxone-treated mares than in saline-treated mares.
Localization (secreted) of oxytocin associated with narcan
19) Confidence 0.79 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.36
During the postpartum period, total amount of oxytocin secreted following vaginocervical stimulation tended to be greater than during the prepartum period, and stimulated oxytocin secretion was significantly greater in naloxone-treated mares than in saline-treated mares.
Localization (secretion) of oxytocin associated with narcan
20) Confidence 0.79 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.38

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