INT289306

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.83
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinb1b) cytoplasm (Serpinb1b)
Anatomy Link Frequency
mouth 1
Serpinb1b (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 85 99.54 Very High Very High Very High
Inflammatory mediators 12 86.20 High High
agonist 95 82.88 Quite High
antagonist 73 77.92 Quite High
tolerance 30 71.76 Quite High
qutenza 25 57.64 Quite High
Inflammation 25 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 301 98.44 Very High Very High Very High
Dyspnea 72 97.56 Very High Very High Very High
Volume Depletion And Dehydration 10 95.28 Very High Very High Very High
Injury 20 93.40 High High
Airway Obstruction 71 86.24 High High
Rhinitis 10 86.16 High High
INFLAMMATION 37 85.80 High High
Seasonal Allergic Rhinitis 5 84.16 Quite High
Hypersensitivity 10 66.76 Quite High
Cough 66 57.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This level of exercise is usually enough to induce EIB in susceptible subjects.15 The effect on the airways maybe further intensified by having the subject breathe cool dry air through their mouth while exercising.17 This can be accomplished by inflating a breathing bag with compressed air from which the subjects breathes.
Positive_regulation (induce) of EIB in mouth
1) Confidence 0.41 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789687 Disease Relevance 0.28 Pain Relevance 0.08
Interestingly the prevalence of EIB and AHR are increased in elite athletes.13 It is suspected that the repeated high ventilation required during training may irritate the airways and result in mediator release and airway injury.
Positive_regulation (increased) of EIB associated with injury
2) Confidence 0.41 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789687 Disease Relevance 0.82 Pain Relevance 0
In another study, adults taking ICS with who continued to demonstrate EIB were either randomized to salmeterol bid or montelukast once daily for four weeks.
Positive_regulation (demonstrate) of EIB associated with corticosteroid
3) Confidence 0.30 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789687 Disease Relevance 0 Pain Relevance 0.27
The observation that cool and/or dry air increases the possibility of EIB led to two theories of its etiology that were debated for years.28,29 One theory concerned a cooling and the other a dehydration of the cells that line the airways.
Positive_regulation (increases) of EIB associated with volume depletion and dehydration
4) Confidence 0.30 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789687 Disease Relevance 0.72 Pain Relevance 0.06
However, it has been shown that while swimming indoors in chlorinated pools, the athlete is exposed to chloramines which have been shown to be asthmagenic34 and a prevalence of EIB as high as 29% has been reported in competitive swimmers.35 Nevertheless it is possible for athletes with asthma induced by running to win Olympic medals in swimming competitions (Kurt Grote: Gold Medal winner at the 1996 Atlanta Olympics) and for many patients there are beneficial effects as well as potential adverse effects from swimming.34 The prevalence of EIB and AHR are increased in some elite athletes.36,37 This may be due to the extreme hyperventilation that occurs during training in some sports.
Positive_regulation (increased) of EIB associated with asthma and dyspnea
5) Confidence 0.30 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789687 Disease Relevance 0.53 Pain Relevance 0.03
A positive response to mannitol is used to identify patients who have exercise-induced bronchoconstriction (EIB), with or without chronic symptoms of asthma.
Positive_regulation (induced) of EIB associated with asthma
6) Confidence 0.07 Published 2009 Journal Lung Section Body Doc Link PMC2816235 Disease Relevance 0.50 Pain Relevance 0.04

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