INT28931

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.42
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (LRPAP1) protein folding (LRPAP1) vesicle-mediated transport (LRPAP1)
endoplasmic reticulum (LRPAP1) plasma membrane (LRPAP1) cytoplasm (LRPAP1)
Anatomy Link Frequency
PCP 1
SVR 1
LRPAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 2 84.88 Quite High
Clonidine 5 82.96 Quite High
headache 2 67.20 Quite High
depression 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
epidural 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 33 88.92 High High
Pressure Volume 2 Under Development 4 87.36 High High
Myocardial Infarction 10 75.00 Quite High
Headache 2 67.20 Quite High
Adult Respiratory Distress Syndrome 84 5.00 Very Low Very Low Very Low
Pulmonary Disease 16 5.00 Very Low Very Low Very Low
Cv General 2 Under Development 16 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 11 5.00 Very Low Very Low Very Low
Pulmonary Heart Disease 10 5.00 Very Low Very Low Very Low
Hypoxia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant decrease of systolic and diastolic BPs, RAP, PCP, SVR and PVR was observed after 1/2 of IS-5-MN administration and was maintained through the study, while CI and CPP increased and HR remained unchanged.
Negative_regulation (decrease) of RAP in PCP
1) Confidence 0.57 Published 1989 Journal Rev Esp Cardiol Section Abstract Doc Link 2813884 Disease Relevance 0.51 Pain Relevance 0.07
A significant decrease of systolic and diastolic BPs, RAP, PCP, SVR and PVR was observed after 1/2 of IS-5-MN administration and was maintained through the study, while CI and CPP increased and HR remained unchanged.
Negative_regulation (decrease) of RAP in SVR
2) Confidence 0.19 Published 1989 Journal Rev Esp Cardiol Section Abstract Doc Link 2813884 Disease Relevance 0.51 Pain Relevance 0.07
The results indicate that preload parameters such as RAP, PCWP and MPAP decreased significantly with the combination therapy but not with captopril alone.
Negative_regulation (decreased) of RAP
3) Confidence 0.18 Published 1997 Journal Hypertension Section Abstract Doc Link 9039154 Disease Relevance 0.30 Pain Relevance 0.37
RAP was significantly higher in the control group than in the nitroglycerin group at baseline, and decreased compared with baseline at T2 (Table 2).
Negative_regulation (decreased) of RAP
4) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1751043 Disease Relevance 0.09 Pain Relevance 0
An increase in venous return comes from an increase in stressed volume, decrease in venous compliance, decrease in resistance to venous return and a decrease in RAP.
Negative_regulation (decrease) of RAP
5) Confidence 0.10 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0 Pain Relevance 0.04
As RAP decreases, venous return increases until the point of flow limitation.
Negative_regulation (decreases) of RAP
6) Confidence 0.08 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0 Pain Relevance 0.03

General Comments

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