INT289317

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.09
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PML) nucleoplasm (PML) endoplasmic reticulum (PML)
intracellular (PML) protein complex assembly (PML) DNA binding (PML)
PML (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 99.80 Very High Very High Very High
Multiple sclerosis 10 98.96 Very High Very High Very High
Infliximab 6 73.88 Quite High
corticosteroid 6 73.40 Quite High
Central nervous system 3 58.00 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Adalimumab 2 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Progressive Multifocal Leukoencephalopathy 37 100.00 Very High Very High Very High
Rheumatoid Arthritis 1 99.80 Very High Very High Very High
Disease 85 99.30 Very High Very High Very High
Demyelinating Disease 13 98.96 Very High Very High Very High
Anaplastic Astrocytoma 1 46.80 Quite Low
Refractory Anemia 1 34.52 Quite Low
Recurrence 2 27.16 Quite Low
Confusion 2 22.76 Low Low
Emergencies 1 20.40 Low Low
Necrosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A retrospective study conducted by Yousry et al of more than 3000 patients who received natalizumab for multiple sclerosis, CrohnÂ’s disease and rheumatoid arthritis found no new case of PML and suggested a risk of developing the disease is about one per thousand patients (0.2 to 2.8 per thousand) treated with natalizumab for a mean duration of 18 months.32
Neg (no) Positive_regulation (new) of Localization (case) of PML associated with progressive multifocal leukoencephalopathy, multiple sclerosis, rheumatoid arthritis and disease
1) Confidence 0.23 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789688 Disease Relevance 1.09 Pain Relevance 0.26

General Comments

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