INT28934

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Context Info
Confidence 0.12
First Reported 1989
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.15
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Anatomy Link Frequency
heart 4
liver 2
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 1 100.00 Very High Very High Very High
tolerance 44 99.86 Very High Very High Very High
Inflammation 4 99.80 Very High Very High Very High
Pain 2 99.80 Very High Very High Very High
Arthritis 7 99.46 Very High Very High Very High
IPN 1 98.72 Very High Very High Very High
Paracetamol 12 96.52 Very High Very High Very High
Glutamate 1 95.16 Very High Very High Very High
Angina 4 95.12 Very High Very High Very High
Clonidine 3 85.80 High High
Disease Link Frequency Relevance Heat
Depression 1 100.00 Very High Very High Very High
Stress 8 99.88 Very High Very High Very High
Arthritis 11 99.46 Very High Very High Very High
Inflammatory Pain 1 98.72 Very High Very High Very High
Injury 3 97.04 Very High Very High Very High
Aging 2 97.00 Very High Very High Very High
Cv General 3 Under Development 4 95.12 Very High Very High Very High
INFLAMMATION 1 94.36 High High
Pressure Volume 2 Under Development 4 92.12 High High
Hepatotoxicity 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adjuvant-induced arthritis resulted in a significant reduction in hepatic cytochrome P-450 levels and in p-nitrophenol glucuronidation (5.65 +/- 0.40 versus 2.58 +/- 0.27 micromol.min/mg protein in control and arthritic rats, respectively, mean +/- S.E.M.).
Negative_regulation (reduction) of Gene_expression (levels) of P-450 associated with arthritis
1) Confidence 0.12 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 9884306 Disease Relevance 0.65 Pain Relevance 0.32
Selective downregulation of hepatic cytochrome P450 expression and activity in a rat model of inflammatory pain.
Negative_regulation (downregulation) of Gene_expression (expression) of P450 associated with inflammation and ipn
2) Confidence 0.04 Published 2005 Journal Pharm. Res. Section Title Doc Link 15771231 Disease Relevance 0.19 Pain Relevance 0.50
Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress.
Negative_regulation (decrease) of Gene_expression (expression) of P450 associated with stress and tolerance
3) Confidence 0.03 Published 2006 Journal Free Radic. Biol. Med. Section Title Doc Link 16520233 Disease Relevance 0.26 Pain Relevance 0.38
In conclusion, because continuous NTG infusion causes vitamin E depletion as well as nitrate tolerance, vitamin E deficiency may further accelerate nitrate tolerance via an increase in oxidative stress, the reduced bioconversion because of decreased P450 expression, and impairment of the NO/cGMP pathway in tolerant heart tissues.
Negative_regulation (decreased) of Gene_expression (expression) of P450 in heart associated with stress and tolerance
4) Confidence 0.03 Published 2006 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16520233 Disease Relevance 0.17 Pain Relevance 0.24
Cardiac P450 expression (CYP1A2) assessed by immunoblotting, markedly decreased 48 h after NTG administration in control rats.
Negative_regulation (decreased) of Gene_expression (expression) of P450
5) Confidence 0.03 Published 2006 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16520233 Disease Relevance 0.23 Pain Relevance 0.41
Conversely, limitation of sulfur-containing amino acids could result in depression of protein synthesis and hepatic cytochrome P450 levels, and hence in decreased reactive metabolite formation and decreased liver injury.
Negative_regulation (depression) of Gene_expression (levels) of P450 in liver associated with depression and injury
6) Confidence 0.03 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2815088 Disease Relevance 0.37 Pain Relevance 0.43
In conclusion, because continuous NTG infusion causes vitamin E depletion as well as nitrate tolerance, vitamin E deficiency may further accelerate nitrate tolerance via an increase in oxidative stress, the reduced bioconversion because of decreased P450 expression, and impairment of the NO/cGMP pathway in tolerant heart tissues.
Negative_regulation (reduced) of Gene_expression (expression) of P450 in heart associated with stress and tolerance
7) Confidence 0.03 Published 2006 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16520233 Disease Relevance 0.17 Pain Relevance 0.24
These changes in GRF-induced, sexually dimorphic secretory growth hormone profiles and the accompanying decline in P450 expression levels may anticipate similar, but more profound, changes to occur during senescence.
Negative_regulation (decline) of Gene_expression (expression) of P450 associated with aging
8) Confidence 0.02 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 11792682 Disease Relevance 0.10 Pain Relevance 0.24
OA treatment also increased the expression of genes related to cell proliferation and suppressed the expression of several cytochrome P450 genes possibly to switch cellular metabolic energy to an acute-phase response.
Spec (possibly) Negative_regulation (suppressed) of Gene_expression (expression) of P450
9) Confidence 0.00 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18706400 Disease Relevance 0 Pain Relevance 0.11

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