INT289357

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.10
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ngfr, Akt1) signal transduction (Ngfr, Akt1) nucleus (Ngfr, Akt1)
plasma membrane (Ngfr, Akt1) cell differentiation (Ngfr) transport (Akt1)
Anatomy Link Frequency
neurons 1
sympathetic 1
oligodendrocytes 1
Ngfr (Rattus norvegicus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 30 92.60 High High
Spinal cord 198 88.16 High High
Demyelination 3 65.64 Quite High
cytokine 3 62.72 Quite High
Inflammatory response 3 59.72 Quite High
withdrawal 21 50.00 Quite Low
Hippocampus 24 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 84 99.64 Very High Very High Very High
Death 30 99.02 Very High Very High Very High
Spinal Cord Injury 99 88.80 High High
Adhesions 3 80.88 Quite High
Injury 15 80.48 Quite High
Demyelinating Disease 3 65.64 Quite High
Necrosis 6 61.08 Quite High
Cancer 6 60.72 Quite High
INFLAMMATION 3 59.36 Quite High
Infection 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of Rac by p75NTR induces apoptosis via activation of JNK in oligodendrocytes [18].
p75NTR Positive_regulation (Activation) of Rac in oligodendrocytes associated with apoptosis
1) Confidence 0.03 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 1.27 Pain Relevance 0.31
Rac/Cdc42 GTPases promote the apoptotic death of NGF-deprived sympathetic neurons [16,17] and activation of Rac by p75NTR induces apoptosis via activation of JNK [18].
p75NTR Positive_regulation (activation) of Rac in sympathetic associated with apoptosis and death
2) Confidence 0.02 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 1.02 Pain Relevance 0.07
For example, Rac/Cdc42 GTPases promote the apoptotic death of NGF-deprived sympathetic neurons [16,17] and activation of Rac by p75 neurotrophin receptor (p75NTR) induces apoptosis via activation of c-jun N-terminal kinase (JNK) in oligodendrocytes [18].
p75NTR Positive_regulation (activation) of Rac in neurons associated with apoptosis and death
3) Confidence 0.02 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.81 Pain Relevance 0.28

General Comments

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