INT289372

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gli1) intracellular (Gli1) cilium (Gli1)
DNA binding (Gli1) cytoplasm (Gli1) cytosol (Gli1)
Gli1 (Mus musculus)
cac (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sunburn 23 81.56 Quite High
Skin Cancer 48 75.36 Quite High
Cancer 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 1 5.00 Very Low Very Low Very Low
Erythema 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Introduction of point mutations that change a specific residue in the acidic transactivation domain of GLI1 significantly reduced GLI1-induced transactivation of the pG5CAT reporter (c.3345 T>G and c.3346 T>C [F1048A]), demonstrating that the assay is sensitive enough to detect functional differences caused by single amino acid changes.
Negative_regulation (reduced) of GLI1-induced Positive_regulation (transactivation) of CAT
1) Confidence 0.48 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2789726 Disease Relevance 0.68 Pain Relevance 0

General Comments

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