INT2894

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1978
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 43
Total Number 43
Disease Relevance 4.59
Pain Relevance 20.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
uterine 8
pituitary 6
posterior lobe 2
brain 2
posterior pituitary 2
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 22 100.00 Very High Very High Very High
Opioid 66 99.98 Very High Very High Very High
Morphine 58 99.98 Very High Very High Very High
narcan 54 99.98 Very High Very High Very High
Endogenous opioid 16 99.98 Very High Very High Very High
Dismenorea 41 99.84 Very High Very High Very High
noradrenaline 8 99.84 Very High Very High Very High
antagonist 40 99.80 Very High Very High Very High
opioid receptor 11 99.68 Very High Very High Very High
anesthesia 9 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 40 99.84 Very High Very High Very High
Nociception 5 99.52 Very High Very High Very High
Stress 10 99.30 Very High Very High Very High
Cognitive Disorder 31 99.00 Very High Very High Very High
Pre-term Labor 3 97.36 Very High Very High Very High
Reprotox - General 1 3 97.20 Very High Very High Very High
Syndrome 1 96.24 Very High Very High Very High
Repression 1 89.44 High High
Sprains And Strains 8 88.96 High High
Pain 1 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine inhibits nocturnal oxytocin secretion and uterine contractions in the pregnant baboon.
Negative_regulation (inhibits) of Localization (secretion) of oxytocin in uterine associated with dismenorea and morphine
1) Confidence 0.58 Published 1998 Journal Biol. Reprod. Section Title Doc Link 9546727 Disease Relevance 0.64 Pain Relevance 1.36
In conclusion, oxytocin secretion to breast-feeding is inhibited by exogenous morphine when compared to a control group but the administration of naloxone did not produce a significant difference from control.
Negative_regulation (inhibited) of Localization (secretion) of oxytocin associated with narcan and morphine
2) Confidence 0.58 Published 1999 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 10394089 Disease Relevance 0 Pain Relevance 0.79
[Opioid inhibition of oxytocin release from the posterior lobe of the hypophysis and its significance for obstetrical anesthesiology].
Negative_regulation (inhibition) of Localization (release) of oxytocin in posterior lobe associated with opioid
3) Confidence 0.57 Published 1992 Journal Anesteziol Reanimatol Section Title Doc Link 1492684 Disease Relevance 0 Pain Relevance 0.58
CONCLUSION: Maternal oxytocin secretion is inhibited by exogenous opiates in the first stage of labour while an effect of opiate antagonism was not demonstrated.


Negative_regulation (inhibited) of Localization (secretion) of oxytocin
4) Confidence 0.57 Published 1992 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 1483291 Disease Relevance 0 Pain Relevance 0
Experiments in rodents have suggested that environmental disturbance can disrupt parturition through an opioid-mediated inhibition of oxytocin secretion.
Negative_regulation (inhibition) of Localization (secretion) of oxytocin associated with opioid
5) Confidence 0.57 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1484848 Disease Relevance 0.07 Pain Relevance 0.28
The review of literature presents modern experimental and clinical data on opioid inhibition of oxytocin release from posterior hypophysis lobe during pregnancy and in childbirth.
Negative_regulation (inhibition) of Localization (release) of oxytocin in hypophysis associated with opioid
6) Confidence 0.57 Published 1992 Journal Anesteziol Reanimatol Section Abstract Doc Link 1492684 Disease Relevance 0 Pain Relevance 0.53
We conclude that the spinal intrathecal administration of fentanyl does not suppress oxytocin secretion in pregnant women who are not in labour at term.
Neg (not) Negative_regulation (suppress) of Localization (secretion) of oxytocin in spinal associated with intrathecal
7) Confidence 0.57 Published 2001 Journal Clin. Sci. Section Abstract Doc Link 11566079 Disease Relevance 0 Pain Relevance 0.37
In conclusion, these data suggest that endogenous opioids suppress oxytocin secretion pre and post partum.
Negative_regulation (suppress) of Localization (secretion) of oxytocin associated with endogenous opioid
8) Confidence 0.57 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.36
The inhibition of basal secretion can occur at the level of the neurosecretory terminals where endogenous opioids inhibit the release of oxytocin, and at the cell bodies of magnocellular cells to modulate the activity pattern of vasopressin cells.
Negative_regulation (inhibit) of Localization (release) of oxytocin associated with endogenous opioid
9) Confidence 0.55 Published 2000 Journal Neurosci. Res. Section Abstract Doc Link 10711808 Disease Relevance 0 Pain Relevance 0.32
This finding is consistent with the hypothesis that the opioid responsible for inhibition of oxytocin release coexists with either oxytocin or vasopressin.
Negative_regulation (inhibition) of Localization (release) of oxytocin associated with opioid
10) Confidence 0.52 Published 1985 Journal Exp Brain Res Section Abstract Doc Link 2995108 Disease Relevance 0 Pain Relevance 0.87
When electrical stimuli are applied to the neural stalk of the pituitary, oxytocin, vasopressin, and probably several opioid peptides also contained in nerve terminals in the gland are released: one action of the released opioids appears to be to inhibit oxytocin release by an action that has been likened to pre-synaptic inhibition.
Negative_regulation (inhibit) of Localization (release) of oxytocin in gland associated with opioid
11) Confidence 0.52 Published 1985 Journal Exp Brain Res Section Abstract Doc Link 2995108 Disease Relevance 0 Pain Relevance 0.64
Thus, it seems unlikely that the enkephalins, putative delta-receptor agonists present in neurohypophysial fibres, are the opioids responsible for the observed inhibition of oxytocin release.
Negative_regulation (inhibition) of Localization (release) of oxytocin associated with agonist, enkephalin and opioid
12) Confidence 0.52 Published 1985 Journal Exp Brain Res Section Abstract Doc Link 2995108 Disease Relevance 0 Pain Relevance 0.83
Pelvic sensory deficits apparently block oxytocin release and disturb both short-latency and long-term maternal behaviors but do not result ultimately in rejection of the calf.
Negative_regulation (block) of Localization (release) of oxytocin
13) Confidence 0.45 Published 2001 Journal Biol. Reprod. Section Abstract Doc Link 11420252 Disease Relevance 0 Pain Relevance 0.19
In conclusion, opioids such as morphine are potent inhibitors of nocturnal UCs and act by suppressing OT release in the pregnant baboon.
Negative_regulation (suppressing) of Localization (release) of OT associated with dismenorea, opioid and morphine
14) Confidence 0.43 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9546727 Disease Relevance 0.52 Pain Relevance 1.25
Endogenous opioids inhibit the stimulated secretion of oxytocin and AVP in vivo in response to vaginocervical stimulation in the goat.
Negative_regulation (inhibit) of Localization (secretion) of oxytocin associated with endogenous opioid
15) Confidence 0.43 Published 1987 Journal J. Endocrinol. Section Abstract Doc Link 3437251 Disease Relevance 0 Pain Relevance 0.41
Oxytocin is known to be inhibited by endogenous opioids at parturition, thus future research should consider the potential role of increased nociception at birth as a negative feedback to oxytocin release.
Negative_regulation (feedback) of Localization (release) of oxytocin associated with nociception and endogenous opioid
16) Confidence 0.42 Published 1997 Journal Pain Section Abstract Doc Link 9272799 Disease Relevance 0.50 Pain Relevance 0.50
The authors call for the development of specific evidence-based guidelines to reduce the likelihood of patient harm by limiting elective use of oxytocin, decreasing the need for indicated use, reducing dosages during necessary use, giving more responsibility and authority for the patient's safety to the professional who is "at the bedside administering and monitoring the oxytocin infusion" (i.e., the nurse), and accepting that "more time rather than more oxytocin is generally preferable" once adequate uterine activity has been achieved.
Negative_regulation (reduce) of Localization (use) of oxytocin in uterine
17) Confidence 0.42 Published 2009 Journal Birth Section Abstract Doc Link 20002429 Disease Relevance 0 Pain Relevance 0.09
Evidence for opioidergic inhibition of oxytocin release in periparturient mares.
Negative_regulation (inhibition) of Localization (release) of oxytocin
18) Confidence 0.42 Published 1996 Journal Theriogenology Section Title Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.28
Breast stimulation contraction stress test: uterine contractions in the absence of oxytocin release.
Negative_regulation (absence) of Localization (release) of oxytocin in uterine associated with stress and dismenorea
19) Confidence 0.42 Published 1986 Journal Am J Perinatol Section Title Doc Link 3942612 Disease Relevance 0.48 Pain Relevance 0.20
The results indicate that, while the intact rabbit uterus under different hormonal influences is not depressed by 1.5 or 3.0 percent enflurane, its response to oxytocin following enflurane is decreased.
Negative_regulation (decreased) of Localization (response) of oxytocin in uterus
20) Confidence 0.42 Published 1978 Journal Anesth. Analg. Section Abstract Doc Link 565151 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox