INT289409

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.64
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Icam5) biological_process (Cd209a)
Anatomy Link Frequency
T-cells 3
Icam5 (Mus musculus)
Cd209a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 86.96 High High
cytokine 69 82.40 Quite High
Pain 3 70.76 Quite High
headache 6 69.20 Quite High
Inflammation 9 67.44 Quite High
tolerance 6 54.96 Quite High
Inflammatory response 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 18 100.00 Very High Very High Very High
Dengue 192 98.88 Very High Very High Very High
Infection 66 95.64 Very High Very High Very High
Dengue Hemorrhagic Fever 93 88.68 High High
Hemorrhage 9 81.28 Quite High
Viral Meningitis 9 78.28 Quite High
Leukopenia 3 76.52 Quite High
Disease 30 71.96 Quite High
Pain 3 70.76 Quite High
Myalgia 6 70.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DC-SIGN has a high affinity for ICAM3 which is expressed in activating T-cells.
ICAM3 Binding (affinity) of DC-SIGN in T-cells
1) Confidence 0.03 Published 2009 Journal Virol J Section Abstract Doc Link PMC2789730 Disease Relevance 2.57 Pain Relevance 0.17
Adhesion molecules such as ICAM1 and ICAM3 are critical molecules generated by the T-cell during either phase and can bind to the adhesion molecules of DCs particularly DC-SIGN which is a known target of dengue.
ICAM3 Binding (bind) of DC-SIGN in T-cell associated with dengue and adhesions
2) Confidence 0.02 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.52 Pain Relevance 0.17
DC-SIGN has a high affinity to the ICAM3 molecules expressed on T-cells with a complicated system of cross talk that can lead to a variety of outcomes[22].
ICAM3 Binding (affinity) of DC-SIGN in T-cells
3) Confidence 0.02 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.56 Pain Relevance 0.04

General Comments

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