INT289426

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0

plasma membrane (ESR1, RXFP1) cell differentiation (RXFP1) nucleoplasm (ESR1) extracellular matrix organization (RXFP1) enzyme binding (ESR1) DNA binding (ESR1)

Anatomy Link Frequency Notch 1 ESR1 (Homo sapiens) RXFP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Sicca syndrome 1 5.00 tolerance 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Adhesions 6 90.00 Uveitis 1 40.00 Disease 2 37.28 Wound Healing 2 8.32 Corneal Disease 10 5.00 Hyperopia 2 5.00 Ocular Injury 2 5.00 Injury 2 5.00 Endometriosis (extended) 2 5.00 Photophobia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These included a variety of genes associated with signal transduction pathways, such as CD47 (binds thrombospondin), jagged 2 (activates Notch receptors), vasoactive intestinal peptide receptor 1 and G protein coupled estrogen receptor 1 (binds estrogen and promotes nongenomic signaling events).

estrogen receptor Binding (coupled) of peptide receptor 1 in Notch

1) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790476 Disease Relevance 0.18 Pain Relevance 0

General Comments

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