INT289462

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6, IL1B) aging (IL1B) DNA binding (IRF6)
cell-cell signaling (IL1B) cytoplasm (IRF6) extracellular space (IL1B)
IRF6 (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 34 97.24 Very High Very High Very High
Inflammation 72 94.12 High High
agonist 29 76.60 Quite High
dexamethasone 43 68.28 Quite High
antagonist 11 61.40 Quite High
Inflammatory response 5 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 81 94.12 High High
Disease 9 5.00 Very Low Very Low Very Low
Ocular Hypertension 7 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Disorders Of The Lacrimal System 3 5.00 Very Low Very Low Very Low
Eye Disease 3 5.00 Very Low Very Low Very Low
Diabetic Macular Edema 3 5.00 Very Low Very Low Very Low
Cataract 2 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BOL-303242-X and TA both inhibited LPS-induced increases in cellular levels of IL-1ß and ICAM-1 in HRECs, and a statistically significant reduction of LPS-induced increases in the cellular levels of IL-1ß and ICAM-1 was observed at doses ranging from 0.1 to 10 µM (Figure 4).


Negative_regulation (inhibited) of LPS Positive_regulation (increases) of IL-1
1) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.31 Pain Relevance 0.41
Failure of KN62 to inhibit LPS-induced IL-1?
Negative_regulation (Failure) of LPS Positive_regulation (induced) of IL-1
2) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.06

General Comments

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