INT289464

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) extracellular space (ICAM1) cell adhesion (ICAM1)
plasma membrane (ICAM1) nucleus (IRF6) DNA binding (IRF6)
IRF6 (Homo sapiens)
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 31 92.72 High High
Inflammation 53 89.60 High High
dexamethasone 43 75.04 Quite High
agonist 7 72.08 Quite High
Potency 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 57 89.60 High High
Ocular Hypertension 7 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Disorders Of The Lacrimal System 3 5.00 Very Low Very Low Very Low
Eye Disease 3 5.00 Very Low Very Low Very Low
Diabetic Macular Edema 3 5.00 Very Low Very Low Very Low
Cataract 2 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 2 5.00 Very Low Very Low Very Low
Glaucoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BOL-303242-X and TA both inhibited LPS-induced increases in cellular levels of IL-1ß and ICAM-1 in HRECs, and a statistically significant reduction of LPS-induced increases in the cellular levels of IL-1ß and ICAM-1 was observed at doses ranging from 0.1 to 10 µM (Figure 4).


Negative_regulation (reduction) of LPS Positive_regulation (increases) of ICAM-1
1) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.31 Pain Relevance 0.50

General Comments

This test has worked.

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