INT289465

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.90
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6, IL1B) aging (IL1B) DNA binding (IRF6)
cell-cell signaling (IL1B) cytoplasm (IRF6) extracellular space (IL1B)
IRF6 (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 74 96.84 Very High Very High Very High
Inflammation 182 93.72 High High
agonist 102 76.20 Quite High
dexamethasone 86 74.08 Quite High
antagonist 44 60.32 Quite High
Inflammatory stimuli 4 49.80 Quite Low
addiction 20 48.48 Quite Low
Inflammatory response 18 18.72 Low Low
imagery 10 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 210 93.72 High High
Targeted Disruption 8 86.72 High High
Disease 32 21.56 Low Low
Ocular Hypertension 14 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Disorders Of The Lacrimal System 6 5.00 Very Low Very Low Very Low
Eye Disease 6 5.00 Very Low Very Low Very Low
Diabetic Macular Edema 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BOL-303242-X and TA both inhibited LPS-induced increases in cellular levels of IL-1ß and ICAM-1 in HRECs, and a statistically significant reduction of LPS-induced increases in the cellular levels of IL-1ß and ICAM-1 was observed at doses ranging from 0.1 to 10 µM (Figure 4).


LPS Positive_regulation (increases) of IL-1
1) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.31 Pain Relevance 0.41
BOL-303242-X and TA both inhibited LPS-induced increases in cellular levels of IL-1ß and ICAM-1 in HRECs, and a statistically significant reduction of LPS-induced increases in the cellular levels of IL-1ß and ICAM-1 was observed at doses ranging from 0.1 to 10 µM (Figure 4).


LPS Positive_regulation (increases) of IL-1
2) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.30 Pain Relevance 0.47
These data are, however, at odds with recent work showing that sustained LPS causes IL-1?
LPS Positive_regulation (causes) of IL-1
3) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.08 Pain Relevance 0.11
Our findings fit with those of Grahames et al. (22) whereby 24-h LPS-induced IL-1?
LPS Positive_regulation (induced) of IL-1
4) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.12 Pain Relevance 0.11
Grahames et al. (22) found no evidence of a role for ATP or the P2X7 receptor in LPS-induced IL-1?
LPS Positive_regulation (induced) of IL-1
5) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.09 Pain Relevance 0
Failure of KN62 to inhibit LPS-induced IL-1?
LPS Positive_regulation (induced) of IL-1
6) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.06

General Comments

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