INT28947

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Context Info
Confidence 0.22
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.78
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1, IGF1) extracellular region (GH1, IGF1) signal transduction (IGF1)
GH1 (Homo sapiens)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 99.48 Very High Very High Very High
Somatostatin 67 99.08 Very High Very High Very High
addiction 2 97.52 Very High Very High Very High
palliative 1 86.24 High High
headache 9 84.56 Quite High
Osteoarthritis 2 75.68 Quite High
imagery 3 69.76 Quite High
agonist 86 69.20 Quite High
dexamethasone 1 50.48 Quite High
Inflammatory marker 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 42 98.92 Very High Very High Very High
Solid Tumor 1 98.64 Very High Very High Very High
Apoptosis 11 95.12 Very High Very High Very High
Acromegaly 67 95.04 Very High Very High Very High
Disease 127 93.48 High High
Osteoporosis 3 90.16 High High
Headache 9 84.56 Quite High
Impaired Glucose Tolerance 4 83.44 Quite High
Cancer 121 82.84 Quite High
Prognathism 2 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the feasibility of a novel form of endocrine therapy that would exploit such dependence, we treated 8 patients with non-endocrine solid tumours with the somatostatin analogue SMS 201-995, in an effort to reduce growth hormone-stimulated IGF-I production.
growth hormone Positive_regulation (stimulated) of Gene_expression (production) of IGF-I associated with addiction, somatostatin and solid tumor
1) Confidence 0.22 Published 1989 Journal Anticancer Res. Section Abstract Doc Link 2817814 Disease Relevance 0.26 Pain Relevance 0.27
GH induces the synthesis of insulin-like growth factor-1 (IGF-1) via hepatic GH receptors; elevated levels of GH and IGF-1 result in metabolic dysfunction and somatic growth.
GH Positive_regulation (induces) of Gene_expression (synthesis) of insulin-like growth factor-1
2) Confidence 0.05 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 1.59 Pain Relevance 0.16
GH induces the synthesis of peripheral insulin-like growth factor I (IGF-I) (Le Roith et al 2001) and endocrine, autocrine and paracrine IGF-I induces cell proliferation and is thought to inhibit apoptosis (O’Reilly et al 2006).
GH Positive_regulation (induces) of Gene_expression (synthesis) of IGF-I associated with apoptosis
3) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.10 Pain Relevance 0.08
GH induces the synthesis of insulin-like growth factor-1 (IGF-1) via hepatic GH receptors; elevated levels of GH and IGF-1 result in metabolic dysfunction and somatic growth.
GH Positive_regulation (induces) of Gene_expression (synthesis) of IGF-1
4) Confidence 0.04 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 1.60 Pain Relevance 0.16
In other animal studies, glucocorticoids decrease GH receptor synthesis and GH-induced IGF-1 mRNA expression [39].
GH Positive_regulation (induced) of Gene_expression (expression) of IGF-1 mRNA
5) Confidence 0.01 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 0.24 Pain Relevance 0.03

General Comments

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