INT289474

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.08
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (GLI2) cell proliferation (GLI2) nucleus (GLI2)
intracellular (GLI2) cilium (GLI2) cytoplasm (GLI2)
Anatomy Link Frequency
monocyte 1
THP-1 1
smooth muscle cells 1
extracellular matrix 1
GLI2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 53 99.84 Very High Very High Very High
cytokine 43 94.08 High High
chemokine 7 94.08 High High
Inflammatory marker 1 88.32 High High
agonist 16 83.68 Quite High
Inflammatory mediators 1 82.00 Quite High
metalloproteinase 6 70.00 Quite High
dexamethasone 43 59.64 Quite High
cINOD 1 36.84 Quite Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 57 99.84 Very High Very High Very High
Adhesions 10 92.48 High High
Glaucoma 2 70.40 Quite High
Ocular Hypertension 7 57.44 Quite High
Hyperglycemia 1 51.72 Quite High
Apoptosis 2 51.12 Quite High
Skin Atrophy 1 48.84 Quite Low
Hypersensitivity 4 39.56 Quite Low
Contact Dermatitis 1 38.12 Quite Low
Eye Disease 3 28.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both collagen I and collagen IV were identified in Fraction 27 but not in any other fraction, and previous studies in our laboratory have shown a pro-migratory effect of collagen I on arterial smooth muscle cells, so we also investigated the effect of these extracellular matrix proteins on THP-1 migration.
Spec (investigated) Regulation (effect) of THP-1 in extracellular matrix
1) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.14
Previous studies in our laboratory established that the platelet releasate had a much greater pro-migratory effect on THP-1 monocytes than on human arterial smooth muscle cells or human retinal endothelial cells (data not shown).
Regulation (effect) of THP-1 in smooth muscle cells
2) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.08
Anti-RANTES neutralizing antibodies had no effect on platelet releasate-induced THP-1 monocyte migration (data not shown).
Neg (no) Regulation (effect) of THP-1 in monocyte
3) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.17
The responsiveness of the monocytic cell line THP-1 to inflammatory challenges was also studied as a systemic benchmark.
Regulation (responsiveness) of THP-1 in THP-1 associated with inflammation
4) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.08 Pain Relevance 0.49

General Comments

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