INT28949

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Context Info
Confidence 0.42
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.03
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
chondrocytes 2
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 6 99.80 Very High Very High Very High
rheumatoid arthritis 77 97.08 Very High Very High Very High
Somatostatin 2 95.92 Very High Very High Very High
palliative 1 93.68 High High
cINOD 3 93.48 High High
addiction 2 92.80 High High
Clonidine 4 91.96 High High
Inflammation 9 76.64 Quite High
tolerance 1 75.88 Quite High
cytokine 21 72.56 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 18 99.96 Very High Very High Very High
Obesity 19 99.88 Very High Very High Very High
Fibromyalgia 5 99.80 Very High Very High Very High
Disease 31 97.80 Very High Very High Very High
Hepatocellular Cancer 13 97.24 Very High Very High Very High
Rheumatoid Arthritis 77 97.08 Very High Very High Very High
Growth Problems 8 96.96 Very High Very High Very High
Hyperinsulinism 3 96.04 Very High Very High Very High
Solid Tumor 1 95.04 Very High Very High Very High
INFLAMMATION 15 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IGF-I generation after one GH injection was reduced in T children than those with GH deficiency (GHD) and constitutional delay of growth and puberty (CDGP).
Negative_regulation (reduced) of Positive_regulation (generation) of IGF-I
1) Confidence 0.42 Published 2009 Journal Hemoglobin Section Abstract Doc Link 20001614 Disease Relevance 0.07 Pain Relevance 0.09
In contrast to patients with fibromyalgia, in whom levels of somatomedin C have been found to be reduced, levels in patients with CFS were found to be elevated.
Negative_regulation (reduced) of Positive_regulation (levels) of somatomedin C associated with fibrositis
2) Confidence 0.41 Published 1997 Journal J Psychiatr Res Section Abstract Doc Link 9201651 Disease Relevance 0.72 Pain Relevance 0.28
In the IGF-I generation test, after GH injection, the thalassaemic children had significantly lower IGF-I and IGFBP-3 levels 86.7 +/- 11.2 ng/ml and 2.05 +/- 0.51 mg/l respectively) than those in the CSS group (226 +/- 45.4 ng/ml and 2.8 +/- 0.43 mg/l respectively).
Negative_regulation (lower) of Positive_regulation (levels) of IGF-I associated with growth problems
3) Confidence 0.40 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.60 Pain Relevance 0.06
From earlier studies it is known that obesity, low levels of IGFBP-1 and an increased IGF-1:IGFBP-1 ratio are factors associated with insulin resistance in men and women [49,51].
Negative_regulation (levels) of Positive_regulation (increased) of IGF-1 associated with obesity and insulin resistance
4) Confidence 0.36 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.38 Pain Relevance 0
First, the preserved levels of IGF-1 in the amino acid groups might contribute since increased levels of IGF-1 is shown to reduce insulin resistance [8,9].
Negative_regulation (reduce) of Positive_regulation (increased) of IGF-1 associated with insulin resistance
5) Confidence 0.36 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.49 Pain Relevance 0
In the Ringer-group we found a pathological metabolic pattern after operation, with depressed IGF-1 and protracted increased levels of glucose and insulin.
Negative_regulation (depressed) of Positive_regulation (increased) of IGF-1
6) Confidence 0.36 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.33 Pain Relevance 0
During their studies, Blunk et al. [11] also found, compared to the standard conditions, a decrease of the glycosaminoglycan fraction, when bovine calf chondrocytes were cultivated with IGF-I and TGF-?
Negative_regulation (decrease) of Positive_regulation (cultivated) of IGF-I in chondrocytes
7) Confidence 0.33 Published 2007 Journal The Open Biomedical Engineering Journal Section Body Doc Link PMC2701085 Disease Relevance 0 Pain Relevance 0
The downregulation of IGF1 and upregulation of a set of another pair of genes might affect a wide variety of cellular functions.


Negative_regulation (downregulation) of Positive_regulation (upregulation) of IGF1
8) Confidence 0.30 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900289 Disease Relevance 0.79 Pain Relevance 0
The pattern of reduced circulating IGF-I and IGFBP-3 with an unchanged GH total production rate in patients with RA, as observed in our study, appears to be consistent with GH resistance or insensitivity [20,25].
Negative_regulation (reduced) of Positive_regulation (circulating) of IGF-I associated with rheumatoid arthritis
9) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 1.09 Pain Relevance 0.30
Significant decreases in basal and arginine-stimulated serum growth hormone and serum IGF-I were noted.
Negative_regulation (decreases) of Positive_regulation (arginine-stimulated) of IGF-I
10) Confidence 0.17 Published 1989 Journal Anticancer Res. Section Abstract Doc Link 2817814 Disease Relevance 0.25 Pain Relevance 0.27
Basal and stimulated GH and IGF-I levels decline with age and with obesity, levels tend to be higher in females and are dependent on nutritional and physical status.
Negative_regulation (decline) of Positive_regulation (stimulated) of IGF-I associated with obesity
11) Confidence 0.04 Published 1996 Journal Horm. Res. Section Abstract Doc Link 8950617 Disease Relevance 0.31 Pain Relevance 0.12

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