INT289496

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.43
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Narfl) cellular_component (Narfl)
Anatomy Link Frequency
blood vessels 1
nerve 1
Narfl (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 99.06 Very High Very High Very High
ischemia 67 81.64 Quite High
anesthesia 18 52.76 Quite High
cytokine 5 20.48 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Adalimumab 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 231 100.00 Very High Very High Very High
Injury 37 98.56 Very High Very High Very High
Death 23 88.56 High High
Optic Disorders 12 87.68 High High
Glaucoma 27 87.56 High High
Cv Unclassified Under Development 48 81.64 Quite High
Stress 1 69.24 Quite High
Cancer 9 50.00 Quite Low
Necrosis 8 50.00 Quite Low
Reperfusion Injury 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While this may be seen as a disadvantage when compared to a more chronic model of IOP elevation, our IOP profile produced a severe injury to the retina that resulted in several features — loss of RGCs and degeneration of the nerve fiber layer, for example — that are common in an inherited mouse model of ocular hypertension [54-57] commonly used to investigate mechanisms of cell death in glaucomatous optic neuropathy.
Gene_expression (elevation) of IOP in nerve associated with injury, ocular hypertension, optic disorders and death
1) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.55 Pain Relevance 0
Indeed, different lasering methods result in different IOP elevation profiles with variations in the time at which the peak IOP is reached and maintained, as well as differences in how long ocular hypertension persists [15,30,89].
Gene_expression (reached) of IOP associated with ocular hypertension
2) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.32 Pain Relevance 0
The retinal blood vessels were visualized by fundus imaging before the IOP was elevated and at increasing levels of IOP.
Gene_expression (levels) of IOP in blood vessels associated with ocular hypertension and imagery
3) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994763 Disease Relevance 0.56 Pain Relevance 0.25

General Comments

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