INT28951
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Treatment of severe primary IGF-1 deficiency | |||||||||||||||
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This problem is more apparent for the elderly where these events are superimposed on an age-related loss in IGF-1 activity. | |||||||||||||||
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Supplemental IGF-1 restored linear growth in these models, linking the suppression of IGF-1 to compromised anabolic activity [43]. | |||||||||||||||
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A reduction of IGF-I levels even in the final stage metastasized prostate cancer may play a major role. | |||||||||||||||
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In these critically-ill patients, the fall in maximal diaphragmatic force over several days parallels the reduction in muscular mass as a result of oxidative myofibrillar injuries, increased protease activity and downregulation of the insulin-like growth factor-I. | |||||||||||||||
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Despite reductions in IGF-1 levels to as low as 239 ng/ml after seven months, the lanreotide dose was increased initially to 90 mg every four weeks, and then to 120 mg every four weeks one month later. | |||||||||||||||
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Although she had no overt symptoms of acromegaly, her cardiac function was improved when her GH and IGF-1 levels were reduced as she had less dyspnoea. | |||||||||||||||
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The reasons for this are unclear as the subjects were otherwise in good health and while rheumatic heart disease is associated with reduced serum IGF-1, rheumatoid arthritis is not [61]. | |||||||||||||||
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Thyroid function was suppressed to reduce IGF-1 levels in glioma patients and high-dose tamoxifen administered. | |||||||||||||||
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The present study shows that it actually also is possible to influence the postoperative decrease in IGF-1 with a balanced amino acid mixture supply. | |||||||||||||||
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During the study period Group B, the Ringer-group, exhibited a decrease in IGF-1 (from 139 to 91 ? | |||||||||||||||
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However, Skjaerbaek et al. found unchanged levels of free IGF-1 despite a significant decrease of total IGF-1 after surgery[45]. | |||||||||||||||
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IGF-1, however, decreased in both group B (139 to101 ? | |||||||||||||||
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After 12 weeks of treatment, mean (+/- SEM) GH levels decreased from 24.8 +/- 12.5 to 6.9 +/- 3.3 ng/ml and mean serum IGF-I levels decreased from 689 +/- 282 to 430 +/- 216 ng/ml. | |||||||||||||||
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Furthermore, insulin-like growth factor (IGF)-1 levels are frequently reduced in patients with FM. | |||||||||||||||
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Indications for treatment of severe IGF-1 deficiency | |||||||||||||||
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Clinical characteristics of primary IGF-1 deficiency | |||||||||||||||
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Etiology of primary IGF-1 deficiency | |||||||||||||||
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Primary IGF-1 deficiency is a rare disease, mainly resulting in very short stature; (2) Mecasermin is a recombinant IGF-1 marketed for this indication as a twice daily subcutaneous injection; (3) Clinical evaluation is mainly based on a non-comparative follow-up study of 76 children with an average age of 7 years, some of whom were treated for 8 years. | |||||||||||||||
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While there are a number of factors including cytokines and poor nutrition, that are thought to contribute to a disruption in IGF-1 functionality [58], the present observations are the first to report that autocrine activation of IGF-1 gene expression in target tissues is a possible solution to these problems. | |||||||||||||||
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General Comments
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